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Rv3919c More about Rv3919c on TBDB.org More about Rv3919c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv3919c: all mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Okamoto S MolMicro 2007 | CCT/CGT | 47 | 16 | Leu/Arg | Before 2000 | Japan | Sequencing | Whole gene | HRSE | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | G257C(rpsL) | - |
| Okamoto S MolMicro 2007 | del G | 102 | 34 | Frameshift | Before 2000 | Japan | Sequencing | Whole gene | R,H,S,E,K,PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | "A276C (gidB); A908G (rrs) " | - |
| Okamoto S MolMicro 2007 | del C | 115 | 39 | Frameshift | Before 2000 | Japan | Sequencing | Whole gene | R, H, S | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | none | - |
| Okamoto S MolMicro 2007 | G/T | 118 | 40 | Glu/STOP | Before 2000 | Japan | Sequencing | Whole gene | H, SM, K, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | A262C(rpsL) | - |
| Okamoto S MolMicro 2007 | G/A | 140 | 47 | Arg/Gln | Before 2000 | Japan | Sequencing | Whole gene | R, H, S, E, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | A908G(rrs) | - |
| Okamoto S MolMicro 2007 | T/G | 164 | 55 | Ile/Ser | Before 2000 | Japan | Sequencing | Whole gene | R, H, S, E, K, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | A276C (gidB), A513C (rrs) | - |
| Okamoto S MolMicro 2007 | G/C | 199 | 67 | Asp/His | After 2000 | Japan | Sequencing | Whole gene | S | 8 ug/ml | Absolute concentration method | 57/132 | 1/0 | none | - |
| Okamoto S MolMicro 2007 | A/C | 208 | 70 | Ser/Arg | Before 2000 | Japan | Sequencing | Whole gene | R, H, S, E, K, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | "A276C (gidB); A513C (rrs) " | - |
| Okamoto S MolMicro 2007 | C/A | 210 | 70 | Ser/Arg | Before 2000 | Japan | Sequencing | Whole gene | R, H, S, E, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | none | - |
| Okamoto S MolMicro 2007 | G/T | 212 | 71 | Gly/Val | Before 2000 | Japan | Sequencing | Whole gene | R, H, S, E, | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | A276C (gidB) | - |
| Okamoto S MolMicro 2007 | C/G | 223 | 75 | Pro/Ala | Before 2000 | Japan | Sequencing | Whole gene | H, S, E, K | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | none | - |
| Spies FS AAC 2008 | TGG/CGG | - | 148 | Trp/Arg | Published 2008 | Brazil | Sequencing | 675bp fragment | H,R,S,E | 15,6 ug/ml | Resazurin microtiter assay | 47/32 | 1/0 | none | - |
| Okamoto S MolMicro 2007 | G/T | 307 | 103 | Glu/STOP | - | Japan | Sequencing | Whole gene | R, H, S, E | N.S | Absolute concentration method | 57/132 | 1/0 | A513C (rrs) | - |
| Okamoto S MolMicro 2007 | del G | 351 | 117 | Frameshift | After 2000 | Japan | Sequencing | Whole gene | S | 8ug/ml | Absolute concentration method | 57/132 | 2/0 | - | - |
| Okamoto S MolMicro 2007 | C/T | 373 | 125 | Gln/STOP | - | Japan | Sequencing | Whole gene | N.S | N.S | Absolute concentration method | 57/132 | 1/0 | - | - |
| Okamoto S MolMicro 2007 | A/C | 380 | 127 | Gln/Pro | - | Japan | Sequencing | Whole gene | N.S | N.S | Absolute concentration method | 57/132 | 1/0 | - | - |
| Okamoto S MolMicro 2007 | C/A | 401 | 134 | Ala/Glu | - | Japan | Sequencing | Whole gene | N.S | N.S | Absolute concentration method | 57/132 | 1/0 | - | - |
| Okamoto S MolMicro 2007 | C/T | 413 | 138 | Ala/Glu | - | Japan | Sequencing | Whole gene | R, H, S, K, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | - | - |
| Okamoto S MolMicro 2007 | C/A | 548 | 183 | Ala/Glu | - | Japan | Sequencing | Whole gene | N.S | N.S | Absolute concentration method | 57/132 | 1/0 | - | - |
| Okamoto S MolMicro 2007 | T/G | 563 | 188 | Val/Gly | - | Japan | Sequencing | Whole gene | R, H, S, E, K, PAS | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | a276C (gidB), G888A (rrs) | - |
| Okamoto S MolMicro 2007 | C/A | 599 | 200 | Ala/Glu | - | Japan | Sequencing | Whole gene | N.S | N.S | Absolute concentration method | 57/132 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |