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Rv0682 More about Rv0682 on TBDB.org More about Rv0682 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv0682: Codons 86 to 87: 3 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Brzostek A IntJ TubLungDis 2004 | CGG/TGG | 256 | 86 | Arg/Trp | 2000 | Poland | Sequencing | region of rpsL | S | N.S | Proportion method, BACTEC 460 | 1/88 | 1/0 | Thr86Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val52Gly, Gly84Val, Arg41Trp, Val87Leu | - |
| Okamoto S MolMicro 2007 | CGG/CCG | 257 | 86 | Arg/Pro | Before 2000 | Japan | Sequencing | - | RHSE | 20 ug/ml | Absolute concentration method | 57/132 | 1/0 | T47G (gidB) | - |
| Brzostek A IntJ TubLungDis 2004 | GTG/TTG | 259 | 87 | Val/Leu | 2000 | Poland | Sequencing | region of rpsL | S | N.S | Proportion method, BACTEC 460 | 1/88 | 1/0 | Thr87Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val52Gly, Gly84Val, Arg86Trp, Val41Leu | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |