Rv0682: rpsLMTB000019: rrsRv3919c: gidB

Rv0682

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Display high confidence mutations only
Rv0682: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Sreevatsan S AAC 1996 CGC/CAC 23 9 Arg/His - - - - - - - - - - -
Brzostek A IntJ TubLungDis 2004 ACC/ATC 119 40 Thr/Ile 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 4/88 4/0 - -
Brzostek A IntJ TubLungDis 2004 ACT/AGT 122 41 Thr/Ser 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 1/88 1/0 Thr41Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val52Gly, Gly84Val, Arg86Trp, Val87Leu -
Nair J Mol Micro 1993 AAG/AGG 128 43 Lys/Arg 1950 USA Sequencing Whole gene S, H, E N.S N.S 40033 1/0 -
Finken M Mol Micro 1993 AAG/ACG 128 43 Lys/Thr 1993 - Sequencing Whole gene MDR N.S Proportion method, BACTEC 460 38/73 5/0 not specified -
Brzostek A IntJ TubLungDis 2004 AAG/AAC 153 51 Lys/Asn 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 1/88 1/0 Thr51Ser is one of 18 silent mutations and 6 a.a. sub: Lys41Asn, Val52Gly, Gly84Val, Arg86Trp, Val87Leu -
Brzostek A IntJ TubLungDis 2004 GTT/GGT 155 52 Val/Gly 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 1/88 1/0 Thr52Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val41Gly, Gly84Val, Arg86Trp, Val87Leu -
Brzostek A IntJ TubLungDis 2004 GGC/GTC 251 84 Gly/Val 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 1/88 1/0 Thr84Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val52Gly, Gly41Val, Arg86Trp, Val87Leu -
Brzostek A IntJ TubLungDis 2004 CGG/TGG 256 86 Arg/Trp 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 1/88 1/0 Thr86Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val52Gly, Gly84Val, Arg41Trp, Val87Leu -
Okamoto S MolMicro 2007 CGG/CCG 257 86 Arg/Pro Before 2000 Japan Sequencing - RHSE 20 ug/ml Absolute concentration method 57/132 1/0 T47G (gidB) -
Brzostek A IntJ TubLungDis 2004 GTG/TTG 259 87 Val/Leu 2000 Poland Sequencing region of rpsL S N.S Proportion method, BACTEC 460 1/88 1/0 Thr87Ser is one of 18 silent mutations and 6 a.a. sub: Lys51Asn, Val52Gly, Gly84Val, Arg86Trp, Val41Leu -
Sreevatsan S AAC 1996 AAG/CAG 262 88 Lys/Gln 1995 Vietnam Sequencing Whole gene S >200ug/ml Proportion method, BACTEC 460 78/139 1/0 GTG/ATG, Val/Met
Finken M Mol Micro 1993 AAG/AGG 263 88 Lys/Arg 1993 - Sequencing Whole gene S N.S Proportion method 38/73 2/0 n/a
Katsukawa C J Appl Micro 1997 AAG/ATG 263 88 Lys/Met - - - - - - - - - - -
Katsukawa C J Appl Micro 1997 AAG/ACG 263 88 Lys/Thr - - - - - - - - - - -
Sreevatsan S AAC 1996 GTG/ATG 277 93 Val/Met - - - - - - - - - - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator