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MTB000019 More about MTB000019 on TBDB.org More about MTB000019 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| MTB000019: Nucleotides 900 to 949: 7 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Honore N AAC 1994 | C/A | 904 | 904 | - | 1994 | N.S. | PCR-SSCP | 530 loop, 912 region | SH | >1280 | Agar dilution method | 39974 | 1/0 | none | - |
| Honore N AAC 1994 | C/G | 904 | 904 | - | - | - | PCR-SSCP | 530 loop, 912 region | SHR | 160 | Agar dilution method | 39974 | 1/0 | none | - |
| Dobner P MolCellProbes 1997 | A/G | 905 | 905 | - | 1996 | Germany, Sierra Leone | Sequencing | 530 loop, 912 region | S | N.S | - | 1/50 | 1/0 | AAG/CAG, 88 Lys/Thr (rpsL) | - |
| Dobner P MolCellProbes 1997 | A/T | 906 | 906 | - | 1996 | Germany, Sierra Leone | Sequencing | 530 loop, 912 region | S | N.S | - | 1/50 | 1/0 | none | - |
| Katsukawa C J Appl Micro 1997 | A/C | 906 | 906 | - | 1992-1994 | Japan | Sequencing | 450-944 | S | 20-200ug/ml | Absolute concentration method | 95/172 | 1/0 | - | ![]() |
| Katsukawa C J Appl Micro 1997 | A/G | 907 | 907 | - | 1992-1994 | Japan | Sequencing | 450-944 | S | 20-200ug/ml | Absolute concentration method | 95/172 | 1/0 | - | - |
| Katsukawa C J Appl Micro 1997 | ins T | 907-908 | 907 | Frameshift | 1992-1994 | Japan | Sequencing | 450-944 | S | 20-200ug/ml | Absolute concentration method | 95/172 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |