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MTB000019 More about MTB000019 on TBDB.org More about MTB000019 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| MTB000019: Nucleotides 500 to 549: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Meier A AAC 1994 | C/T | 512 | 512 | - | - | - | Sequencing | "505 bp gene fragment; complete S12 gene" | RHS | N.S | Proportion method | 3/38 | 1/0 | - |  |
| Honore N AAC 1995 | ins C | 512 | 512 | Frameshift | - | - | - | - | N.S | N.S | - | - | - | - | - |
| Dobner P MolCellProbes 1997 | A/C | 513 | 513 | - | 1996 | Germany, Sierra Leone | Sequencing | 530 loop, 912 region | S | N.S | - | 1/50 | 1/0 | AAG/AGG, 43 Lys/Arg (rpsL) | |
| Katsukawa C J Appl Micro 1997 | A/T | 513 | 513 | - | 1992-1994 | Japan | Sequencing | 450-944 | S | 20-200ug/ml | Absolute concentration method | 95/172 | 9/0 | - | |
| Dobner P MolCellProbes 1997 | C/T | 516 | 516 | - | 1996 | Germany, Sierra Leone | Sequencing | 530 loop, 912 region | S | N.S | - | 1/50 | 1/0 | none | |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |