Rv0682: rpsLMTB000019: rrsRv3919c: gidB

MTB000019

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Display high confidence mutations only
MTB000019: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Ramaswamy SV J Med Micro 2004 G/A 189 189 - 1996-1998 Mexico Sequencing Whole rrs RHS N.S Proportion method 39838 1/0 "15 ups; C/T (inhA)" -
Ramaswamy SV J Med Micro 2004 G/T 426 426 - 1996-1998 Mexico Sequencing Whole rrs RHS N.S Proportion method 39838 1/0 "315, AGC/ACC, Ser/Thr (katG); 450, TCG/TTG, Ser/Leu (rpoB)" -
Spies FS AAC 2008 G/C 426 426 - Published 2008 Brazil Sequencing 530 loop, 912 region RHSE >31,5ug/ml Resazurin microtiter assay 47/32 1/0 "gidB: CCT/CGT; L16R" -
Brzostek A IntJ TubLungDis 2004 C/T 461 461 - 2000 Poland Sequencing 530 loop, 912 region S N.S Proportion method 4/88 4/0 none -
Meier A AAC 1994 C/T 491 491 - - - Sequencing Whole rrs HS N.S Proportion method 3/38 1/0 -
Meier A AAC 1994 C/T 512 512 - - - Sequencing "505 bp gene fragment; complete S12 gene" RHS N.S Proportion method 3/38 1/0 -
Honore N AAC 1995 ins C 512 512 Frameshift - - - - N.S N.S - - - - -
Dobner P MolCellProbes 1997 A/C 513 513 - 1996 Germany, Sierra Leone Sequencing 530 loop, 912 region S N.S - 1/50 1/0 AAG/AGG, 43 Lys/Arg (rpsL)
Katsukawa C J Appl Micro 1997 A/T 513 513 - 1992-1994 Japan Sequencing 450-944 S 20-200ug/ml Absolute concentration method 95/172 9/0 -
Dobner P MolCellProbes 1997 C/T 516 516 - 1996 Germany, Sierra Leone Sequencing 530 loop, 912 region S N.S - 1/50 1/0 none
Brzostek A IntJ TubLungDis 2004 G/C 627 627 - 2000 Poland Sequencing 530 loop, 912 region S N.S Proportion method, BACTEC 460 1/88 1/0 none -
Sreevatsan S AAC 1996 C/T 798 798 - 1995 USA Sequencing 530 loop, 912 region S N.S Proportion method, BACTEC 460 39814 1/0 "only NY isolate with both rrs and rpsL (AAG/AGG; K43-->R) mutations " -
Cooksey RC, AAC 1996 C/G 865 865 - 1994 USA Sequencing 306 bp RHS 10 Agar dilution method 45/367 1/0 none -
Okamoto S MolMicro 2007 G/A 887 887 - Before 2000 Japan Sequencing - R, H, S, E, K, PAS 20 ug/ml Absolute concentration method 57/132 1/0 A276C, T563G (gidB) -
Honore N AAC 1994 C/A 904 904 - 1994 N.S. PCR-SSCP 530 loop, 912 region SH >1280 Agar dilution method 39974 1/0 none -
Honore N AAC 1994 C/G 904 904 - - - PCR-SSCP 530 loop, 912 region SHR 160 Agar dilution method 39974 1/0 none -
Dobner P MolCellProbes 1997 A/G 905 905 - 1996 Germany, Sierra Leone Sequencing 530 loop, 912 region S N.S - 1/50 1/0 AAG/CAG, 88 Lys/Thr (rpsL) -
Dobner P MolCellProbes 1997 A/T 906 906 - 1996 Germany, Sierra Leone Sequencing 530 loop, 912 region S N.S - 1/50 1/0 none -
Katsukawa C J Appl Micro 1997 A/C 906 906 - 1992-1994 Japan Sequencing 450-944 S 20-200ug/ml Absolute concentration method 95/172 1/0 -
Katsukawa C J Appl Micro 1997 A/G 907 907 - 1992-1994 Japan Sequencing 450-944 S 20-200ug/ml Absolute concentration method 95/172 1/0 - -
Katsukawa C J Appl Micro 1997 ins T 907-908 907 Frameshift 1992-1994 Japan Sequencing 450-944 S 20-200ug/ml Absolute concentration method 95/172 1/0 - -
Sekigushi J JCM 2007 ins C 1061 1061 Frameshift 2006 Japan Multiplex PCR 530 loop, 912 region N.S N.S Proportion method, Rapid broth method 55/138 1/0 Lys121Lys (rpsL), silent mutation, not assoc w/ STR-res. -
Ramaswamy SV J Med Micro 2004 T/C 1238 1238 - 1996-1998 Mexico Sequencing Whole rrs RHSE N.S Proportion method 39897 3/0 "315, AGC/ACC, Ser/Thr (katG); 435, GAC/GTC, Asp/Val (rpoB); 43, AAG/AGG, Lys/Arg (rpsL); 306, ATG/CTG, Met/Leu (embB)" -
Sekigushi J JCM 2007 A/G 1400 1400 - 2006 Japan Multiplex PCR 428-1737 N.S N.S Proportion method, Rapid broth method 55/138 1/0 Lys121Lys (rpsL), silent mutation, not assoc w/ STR-res. -
Sekigushi J JCM 2007 A/G 1539 1539 - 2006 Japan Multiplex PCR 428-1737 N.S N.S Proportion method, Rapid broth method 55/138 1/0 "A1400G (rrs); Lys121Lys (rpsL), silent mutation, not assoc w/ STR-res." -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator