Rv3795: embBRv0667: rpoB

Rv0667

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Rv0667: high confidence mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Kapur V JCM 1994 CTG/CCG - 511 Leu/Pro Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 4/0 "One of the strains was also Asp441Glu; another was Asp441Tyr; the third was also Ser437Thr."
Kapur V JCM 1994 CAA/CTA - 513 Gln/Leu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced.
Kapur V JCM 1994 GAC/GTC - 516 Asp/Val Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced.
Kapur V JCM 1994 GAC/TAC - 516 Asp/Tyr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 Also mutated at Leu436Pro.
Bodmer T JAC 1995 TCG/TTG - 522 Ser/Leu Published 1998 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (1/0) -
Ramaswamy SV J Med Micro 2004 CAC/AAC - 526 His/Asn 1996-2001 Mexico Sequencing - RHSE N.S. Proportion method 37/50 (1/0) "rpoB: Double mutation with 435 GAC/GAG; embB: 306 ATG/ATA1 "
Kapur V JCM 1994 CAC/GAC - 526 His/Asp Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 8/0 None described in the region sequenced.
Kapur V JCM 1994 CAC/TAC - 526 His/Tyr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 39/0 None described in the region sequenced.
Kim BJ JCM 1997 CAC/CGC - 526 His/Arg Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified.
Kapur V JCM 1994 CAC/CTC - 526 His/Leu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced.
Donabella V Am J Respir Cell Mol Biol 1994 TCG/TTG - 531 Ser/Leu Published 1994 USA Sequencing RRDR R N.S. - (1/9) (1/0) -
Bodmer T JAC 1995 TCG/TGG - 531 Ser/Trp Published 2005 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (1/0) -
Moghazeh SL AAC 1996 CTG/CCG - 533 Leu/Pro 1992-1995 USA Sequencing N.S R >32ug/ml Proportion method 24/24 1/0 None described in the region sequenced.

rpoB disclaimer: All mutation coordinates are in reference to E. coli and not M. tuberculosis.

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator