Rv3795: embBRv0667: rpoB

Rv0667

More about Rv0667 on    TBDB.org

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Display high confidence mutations only
Rv0667: Codons 550 to 574: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Pozzi G JCM 1999 TCG/GCG - 553 Ser/Ala Published 2003 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 32-128 ug/ml Proportion method 37/37 (1/0) Triple mutation with CAC526GAC and GAG541GAT -
Ramaswamy SV J Med Micro 2004 ATC/GTC - 561 Ile/Val 1996-1998 Mexico Sequencing RRDR RHSE N.S. Proportion method 37/50 (1/0) "rpoB: Double mutation with 450 TCG/TTG; embB: 306 ATG/ATA" -
Heep M JCM 2001 ATC/ACC - 561 Ile/Thr 1997 Germany Sequencing RRDR N.S. N.S. Proportion method 111/111 (1/0) Double mutation with S456L -
Hauck Y JAC 2009 GAA/GGA - 562 Glu/Gly Published 2009 Various Sequencing RRDR R <1 ug/ml MGIT 960 122/122 1/0 rpoB P564L -
Hauck Y JAC 2009 CCT/CTT - 564 Pro/Leu Published 2009 Various Sequencing RRDR R <1 ug/ml MGIT 960 122/122 1/0 rpoB E562G -
Heep M JCM 2001 CTG/GTG - 571 Leu/Val 1997 Germany Sequencing RRDR RHEZ N.S. Proportion method 111/111 (2/0) Double mutation with D441Y -
Yuen LK JCM 1999 ATC/TTC - 572 Ile/Phe 1990-1997 Vietnam Sequencing RRDR RHE > 256 ug/ml Resistance ratio method, BACTEC 460, E-test 33/50 (1/0) None -
Chan RCY JAC 2007 TCG/TTG - 574 Ser/Leu 1994-2004 Hong Kong PCR-SSCP, Sequencing RRDR RHEZ >64 ug/ml Absolute concentration method. 221/250 1 katG 311 Asp/Gly -

rpoB disclaimer: All mutation coordinates are in reference to E. coli and not M. tuberculosis.

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator