Rv3795: embBRv0667: rpoB

Rv0667

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Display high confidence mutations only
Rv0667: Codons 525 to 549: 38 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Valim A JCM 2000 ACC/CCC - 525 Thr/Pro 1996-1998 Brazil Sequencing RRDR MDR N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)" -
Pozzi G JCM 1999 ACC/ATC - 525 Thr/Ile Published April 2001 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 8-128ug/ml Proportion method 37/37 (1/0) Triple mutation with GAC516TAC and GGG523TGG -
Bahrmand AR JCM 2009 CAC/TTC - 526 His/Phe 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB S512T, G513N, S531L -
Ramaswamy SV J Med Micro 2004 CAC/AAC - 526 His/Asn 1996-2001 Mexico Sequencing - RHSE N.S. Proportion method 37/50 (1/0) "rpoB: Double mutation with 435 GAC/GAG; embB: 306 ATG/ATA1 "
Kapur V JCM 1994 CAC/GAC - 526 His/Asp Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 8/0 None described in the region sequenced.
Kapur V JCM 1994 CAC/TAC - 526 His/Tyr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 39/0 None described in the region sequenced.
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/ACC - 526 His/Thr - - - - - - - - - - -
Prammananan T CMI 2008 CAC/AGC - 526 His/Ser 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 515 ATG/CTG -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/GGC - 526 His/Gly - - - - - - - - - - -
Kim BJ JCM 1997 CAC/TGC - 526 His/Cys Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 2/0 Location of double mutants not specified. -
Kim BJ JCM 1997 CAC/CGC - 526 His/Arg Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified.
Bodmer T JAC 1995 CAC/CCC - 526 His/Pro Published 2001 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (2/0) - -
Valim A JCM 2000 CAC/CTG - 526 His/Leu 1996-1998 Brazil Sequencing RRDR RHSEZEth N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 527 del AAG(Lys)" -
Sheng J JApplMicro 2008 CAC/CTT - 526 His/Leu 2002-2003 China PCR-SSCP , Sequencing RRDR R N.S. Agar proportion method 49/56 1/0 None in rpoB -
Kapur V JCM 1994 CAC/CTC - 526 His/Leu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced.
Kapur V JCM 1994 CAC/CAA - 526 His/Gln Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 Also mutated at Ser456Cys. -
Bodmer T JAC 1995 CAC/CAG - 526 His/Gln Published 2003 N.S. PCR-SSCP RRDR R >8ug/ml BACTEC 460 26/36 (2/0) Double mutation with 498 Val/Ala -
Siddiqi N AAC 2002 AAG/AAT - 527 Lys/Asn 1995-1998 India Sequencing RRDR HRH 40 ug/ml Proportion method 94/126 (2/0) "1) katG or inhA R463L; 2) katG or inhA R463L, rpoB dual mutation with L521L" -
Valim A JCM 2000 del AAG - 527 del Lys 1996-1998 Brazil Sequencing RRDR RHSEZEth N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu)" -
Williams D AAC 1994 AAG/CAG - 527 Lys/Gln Published 1995 USA PCR-HDF, Sequencing RRDR RHEEt N.S. Proportion method 108/120 (1/0) Double mutation with 526 (His) -
Siddiqi N AAC 2002 CGC/CAC - 528 Arg/His 1995-1998 India Sequencing RRDR HR, ROS 64-128 ug/ml Proportion method 94/126 (2/0) "1) rpoB dual mutation with H526Y; gyrA S95T; rpsL NM; 2) rpoB 1 dual mutation with with S531W; katG and inhA R463L, Inh (C/T)" -
Siddiqi N AAC 2002 CGC/CCC - 528 Arg/Pro 1995-1998 India Sequencing RRDR ROS, RHO, RHS, RH 40-64 ug/ml* Proportion method 94/126 (4/0) "1) rpoB dual mutation with N518T; gyrA S95T; rpsL NM; 2) katG or inhA NA; gyrA S95T; 3) katG or inhA R463L; rpsL K121K; 4) katG or inhA R463L; rpoB dual mutation with H526Y" -
Zenteno-Cuevas R MemInstOswaldCruz 2009 CGC/CCT - 528 Arg/Pro 2007 Mexico Sequencing RRDR HRSEZ N.S. BACTEC 460 15/25 1/0 None -
Wang Q JProtRes 2007 TCG/TAG - 538 Leu/STOP Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCG/CAG - 531 Ser/Gln - - - - - - - - - - -
Donabella V Am J Respir Cell Mol Biol 1994 TCG/TTG - 531 Ser/Leu Published 1994 USA Sequencing RRDR R N.S. - (1/9) (1/0) -
Bodmer T JAC 1995 TCG/TGG - 531 Ser/Trp Published 2005 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (1/0) -
Bodmer T JAC 1995 TCG/TAT - 531 Ser/Tyr Published 2006 N.S. PCR-SSCP RRDR R >8ug/ml BACTEC 460 26/36 (1/0) - -
Hillemann D AAC 2005 TCG/TTT - 531 Ser/Phe 2001 Germany real-time sequencing RRDR MDR N.S. - 103/113 (2/0) katG 315 AGC-ACC/Ser-Thr -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCG/TGT - 531 Ser/Cys - - - - - - - - - - -
Moghazeh SL AAC 1996 CTG/CCG - 533 Leu/Pro 1992-1995 USA Sequencing N.S R >32ug/ml Proportion method 24/24 1/0 None described in the region sequenced.
Valim A JCM 2000 CTG/CCT - 533 Leu/Pro 1996-1998 Brazil Sequencing RRDR RH, RHS N.S. Proportion method 82/100 (2/0) Same isolate had double mutation: 526 CAC(His)/CTG(Leu) -
Tracevska T JCM 2002 CCC/TCC - 535 Pro/Ser 1999-2000 Latvia Line probe assay, Sequencing RRDR R, RH N.S. Absolute concentration method, BACTEC 51/70 (4/0) Double mutation with D516Y -
Prammananan T CMI 2008 CCC/CAC - 535 Pro/His 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 526 CAC/AGC His/Ser -
Wang Q JProtRes 2007 CTG/CCG - 538 Leu/Pro Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Prammananan T CMI 2008 GAG/GGG - 541 Glu/Gly 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 526 CAC/TAC His/Tyr -
Pozzi G JCM 1999 GAG/GAT - 541 Glu/Gly Published 2002 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 32-128 ug/ml Proportion method 37/37 (1/0) Triple mutation with CAC526GAC and TCG553GCG -
Aslan G JpnJInfectDis 2008 CTG/ATG - 545 Leu/Met 2003-2006 Turkey Sequencing RRDR R or MDR N.S. BACTEC 460 19/41 3/0 rpoB S531A, katG S315T -

rpoB disclaimer: All mutation coordinates are in reference to E. coli and not M. tuberculosis.

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator