Rv3795: embBRv0667: rpoB

Rv0667

More about Rv0667 on    TBDB.org

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Display high confidence mutations only
Rv0667: Codons 500 to 524: 81 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Schilke K IntJTubLungDis 1999 GAG/GCG - 504 Glu/Ala Published 1999 South Africa Sequencing RRDR MDR N.S. Not specified 105/105 (2/0) Double mutation with 531 -
Heym B Lancet 1994 TTC/TTG - 505 Phe /Leu 1991-1992 La Reunion PCR-SSCP - RSHE > 100 mg/L Proportion method 13/39 (2/0) "1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present" -
Stavrum R PlosOne 2009 TTC/TTA - 505 Phe /Leu Published 2009 India Sequencing Whole gene RSHE > 100 mg/L Proportion method 13/39 (2/0) "1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present" -
Wang Q JProtRes 2007 TTC/TCC - 505 Phe/Ser Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Bahrmand AR JCM 2009 GGC/AGC - 507 Gly/Ser 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR <50 ug/ml Proportion method 41/286 1/0 rpoB T508P -
Kim BJ JCM 1997 GGC/GAC - 507 Gly/Asp Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified. -
Bahrmand AR JCM 2009 GGC/GAT - 507 Gly/Asp 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB Q513STOP, H526Y, S531F -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del GGC ACC - 507-508 del Gly Thr - - - - - - - - - - -
Bahrmand AR JCM 2009 ACC/CAC - 508 Thr/His 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 6/0 rpoB H526Q, S531F -
Bahrmand AR JCM 2009 ACC/CCC - 508 Thr/Pro 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR <50 ug/ml Proportion method 41/286 4/0 rpoB G507S -
Bahrmand AR JCM 2009 ACC/GCC - 508 Thr/Ala 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR <75 ug/ml Proportion method 41/286 2/0 rpoB G523A -
Mani C JCM 2001 ACC/AGC - 508 Thr/Ser Published 2001 India Sequencing RRDR R >128ug/ml Proportion method 44/50 1/0 None described in the region sequenced. -
Matsiota-Bernard P JCM 1998 ACC/GCT - 508 Thr/Ser 1995-1996 Greece Line probe assay, Sequencing RRDR RHSEth N.S. Proportion method 17/17 1/0 None described in the region sequenced. -
Zenteno-Cuevas R MemInstOswaldCruz 2009 AGC/CAG - 509 Ser/Gln 2007 Mexico Sequencing RRDR HRSEZ N.S. BACTEC 460 15/25 1/0 None -
Williams D AAC 1994 AGC/ACC - 509 Ser/Thr Published 1994 Canada Sequencing RRDR RHES N.S. Proportion method 108/120 (1/0) Double mutation with 526 (Asp) -
Sekiguchi J JCM 2007 Jan AGC/AGG - 509 Ser/Arg Published 2007 Japan Sequencing RRDR R, MDR N.S. Proportion method, BACTEC 28/138 (0/1) - -
Zenteno-Cuevas R MemInstOswaldCruz 2009 CAG/AAG - 510 Gln/Lys 2007 Mexico Sequencing RRDR HREZ N.S. BACTEC 460 15/25 1/0 None -
Sajduda A JCM 2004 CAG/CAC - 510 Gln/His 2000 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (2/0) rpoB: double mutation with 516 GAC/TAC -
Kapur V JCM 1994 CTG/CCG - 511 Leu/Pro Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 4/0 "One of the strains was also Asp441Glu; another was Asp441Tyr; the third was also Ser437Thr."
Kapur V JCM 1994 CTG/CGG - 511 Leu/Arg Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced. -
Siddiqi N AAC 2002 CTG/GTG - 511 Leu/Val 1995-1998 India Sequencing RRDR R,O Not listed in Table Proportion method 94/126 (2/0) "1) rpoB dual mutation with N518T; gyrA S95T; 2) gyrA S95T" -
Kapur V JCM 1994 AGC/ACC - 512 Ser/Thr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 Also mutated at Leu436Pro. -
Sajduda A JCM 2004 AGC/ATC - 512 Ser/Ile 2001 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (1/0) rpoB: double mutation with 516 GAC/GGC -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/CGC - 512 Ser/Arg - - - - - - - - - - -
Chan RCY JAC 2007 AGC/GGC - 512 Ser/Gly 1994-2004 Hong Kong PCR-SSCP, Sequencing RRDR - - Absolute concentration method 250 221 - -
Bahrmand AR JCM 2009 CAA/TAA - 513 Gln/STOP 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB G507D, H526Y, S531F -
Bahrmand AR JCM 2009 CAA/AAT - 513 Gly/Asn 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB S512T, H526F, S531L -
Kapur V JCM 1994 CAA/CTA - 513 Gln/Leu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced.
Kapur V JCM 1994 CAA/AAA - 513 Gln/Lys Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced. -
Prammananan T CMI 2008 CAA/GAA - 513 Gln/Glu 2003-2005 Thailand Sequencing Whole gene R N.S. Proportion method, BACTEC 154/113 1/0 None described in the region sequenced. -
Kim BJ JCM 1997 CAA/CCA - 513 Gln/Pro Published 1997 South Korea Sequencing RRDR R N.S. Absolute concentration method. 32/58 2/0 Location of double mutants not specified. -
Valim A JCM 2000 CAA/CAC - 513 Gln/His - - - - - - - 82/100 1/0 - -
Secondary Publication: O'Sullivan DM JAntiChemo 2005 CAA/CGA - 513 Gln/Arg - - - - - - - - - - -
Kapur V JCM 1994 ins TTC - 513-514 ins Phe Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced. -
Kapur V JCM 1994 ins TTC ATG - 513-514 ins Phe Met Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del CAA TTC - 513-514 del Gln Phe - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del AA TTC ATG G - 513-516 Gln/His and del Phe Met - - - - - - - - - - -
Valim A JCM 2000 del TTC - 514 del Phe 1996-1998 Brazil Sequencing RRDR RHSZEth N.S. Proportion method 82/100 (1/0) Same isolate had deletions: 515 (ATG-Met), 516(GAC-Asp) and change in codon 513 CAA(Gln)/CAC(His) -
Taniguchi H FEMS Micro 1996 TTC/TTG - 514 Phe/Leu Published 1996 Japan Sequencing Whole gene R 12.5 ug/ml Proportion method, absolute concentration method 21/39 (1/0) - -
Valim A JCM 2000 TTC/GTC - 514 Phe/Val 1996-1998 Brazil Sequencing RRDR RHSZEth N.S. Proportion method 82/100 (1/0) Same isolate had change in codon 531 TCG(Ser)/TTG(Leu) -
Cavusoglu C JCM 2002 ins CGG - 514-515 ins Arg Published 2002 Turkey Line probe assay, Sequencing RRDR R, RE, RHE, RH, RHES, RHS N.S. Proportion method 41/41 (1/0) - -
Lipin MY CMI 2007 del C AT - 514-515 Phe/Leu and del Met 1998-2001 Russia Sequencing RRDR RHS, RHSK, RHSE N.S. Absolute concentration method. 217/217 1/0 None described in the region sequenced. -
Valim A JCM 2000 del TTC ATG GAC - 514-516 del Phe Met Asp 1996-1998 Brazil Sequencing RRDR RHSZEth N.S. Proportion method 82/100 (1/0) Same isolate had change in codon 513 CAA(Gln)/CAC(His) -
Hillemann D Int J Tuberc Lung Dis 2005 ins TTC - 515 ins Phe 2004 Kazakhstan, Germany real-time sequencing FRET RRDR MDR N.S. N.S. 92/152 (1/0) - -
Sajduda A JCM 2004 ATG/ATT - 515 Met/Ile 2003 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (8/0) rpoB: double mutation with 516 GAC/TAC -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATG/ATA - 515 Met/Ile - - - - - - - - - - -
Valim A JCM 2000 del ATG GAC CAG AAC - 515-518 del Met Asp Gln Asn 1996-1998 Brazil Sequencing RRDR RHSEZEth N.S. Proportion method 82/100 (1/0) - -
Schilke K IntJTubLungDis 1999 GAC/AAC - 516 Asp/Asn Published 1999 South Africa Sequencing RRDR MDR N.S. N.S. 105/105 (1/0) - -
Bahrmand AR JCM 2009 GAC/CAC - 516 Asp/His 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR 50-75 ug/ml Proportion method 41/286 3/0 rpoB D516H, H526R -
Kapur V JCM 1994 GAC/GTC - 516 Asp/Val Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced.
Kapur V JCM 1994 GAC/GAG - 516 Asp/Glu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 Also mutated at Leu436Pro. -
Hillemann D Int J Tuberc Lung Dis 2005 GAC/GGC - 516 Asp/Gly 2004 Kazakhstan, Germany real-time sequencing FRET RRDR MDR N.S. N.S. 92/152 (1/0) - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC - 516 Asp/Ala - - - - - - - - - - -
Sajduda A JCM 2004 GAC/GTG - 516 Asp/Val 2004 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (1/0) None -
Kapur V JCM 1994 GAC/TAC - 516 Asp/Tyr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 Also mutated at Leu436Pro.
Hillemann D Int J Tuberc Lung Dis 2005 GAC/TTC - 516 Asp/Phe 2004 Kazakhstan, Germany real-time sequencing FRET RRDR MDR N.S. N.S. 92/152 (1/0) - -
Kapur V JCM 1994 del GAC CAG - 516-517 del Asp Gln Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced. -
Xueqiong W MolBiotech 2009 GAC/CAC - 517 Gln/His 2002-2005 China Sequencing RRDR RSE N.S. Absolute concentration method 112/148 1/0 rpoB N518D -
Mani C JCM 2001 del GAC - 517 del Gln Published 2001 India Sequencing RRDR R >128ug/ml Proportion method 44/50 1/0 None described in the region sequenced. -
Sajduda A JCM 2004 CAA/CTA - 517 Gln/Leu 2005 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (1/0) None -
Hillemann D AAC 2005 del CAG AAC - 517-518 del Gln Asn 2001 Germany real-time sequencing RRDR MDR N.S. - 103/113 (1/0) katG 315 AGC-ACC/Ser-Thr -
Kapur V JCM 1994 del CAG AAC - 517-518 del Gln Asn Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del G AAC AA - 517-519 Gln/His and del Asn Asn - - - - - - - - - - -
Wang Q JProtRes 2007 AAC/TAC - 518 Asn/Tyr Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Siddiqi N AAC 2002 AAC/ACC - 518 Asn/Thr 1995-1998 India Sequencing RRDR RHO, ROS, RO, RH N.S. Proportion method 94/126 (6/0) "1) rpoB dual mutaton with L511L; katG and inhA NM; gyrA A90A, S95T 3) rpoB dual mutation with R528P; gyrA S95T; rpsL NM; 4) rpoB dual mutaton with L511V; gyrA S95T; 5) gyrA S95T; 6) gyrA NM; 7) rpoB dual mutation with D516V; katG and inhA R463L" -
Hillemann D AAC 2005 AAC/ATC - 518 Asn/Ile 2001 Germany real-time sequencing RRDR MDR N.S. - 103/113 (1/0) None -
Kim BJ JCM 1997 AAC/CAC - 518 Asn/His Published 1997 South Korea Sequencing and PCR-SSCP RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified. -
Chan RCY JAC 2007 AAC/GAC - 518 Asn/Asp 1994-2004 Hong Kong PCR-SSCP, Sequencing RRDR - - Absolute concentration method. 250 221 - -
Bahrmand AR JCM 2009 AAC/AAG - 519 Asn/Lys 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR 50 ug/ml Proportion method 41/286 2/0 rpoB L511V, Q513E, H526R -
Heym B Lancet 1994 del AAC - 519 del Asn 1991-1992 Russia, Netherlands PCR-SSCP - MDR 10-100ug/ml Proportion method 13/39 (2/0) "1) katG mutation present; inhA no mutation present; 2) katG no mutation present" -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CTG/ATG - 521 Leu/Met - - - - - - - - - - -
Taniguchi H FEMS Micro 1996 CTG/CCG - 521 Leu/Pro Published 1998 Japan Sequencing Whole gene R < 0.39 ug/ml Proportion method, absolute concentration method 21/39 (0/1) - -
Secondary Publication: O'Sullivan DM JAntiChemo 2005 CTG/CTA - 521 Leu/Leu - - - - - - - - - - -
Bodmer T JAC 1995 TCG/TTG - 522 Ser/Leu Published 1998 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (1/0) -
Yuen LK JCM 1999 TCG/CAG - 522 Ser/Gln 1990-1997 Timor Sequencing RRDR RH 32-256 ug/ml Resistance ratio method, ,BACTEC 460, E-test 33/50 (2/0) None -
Secondary Publication: O'Sullivan DM JAntiChemo 2005 TCG/TGG - 522 Ser/Trp - - - - - - - - - - -
El Baghdadi J IJTLD 2003 CCC/ACC - 523 Gly/Trp 1996-2001 Morocco Sequencing RRDR RHS N.S. Resistance ratio method 101/122 (1/0) - -
Pozzi G JCM 1999 GGG/TGG - 523 Gly/Trp Published April 2000 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 8-128ug/ml Absolute concentration method 37/37 (1/0) Triple mutation with GAC516TAC and ACC525ATC -
Bahrmand AR JCM 2009 GGG/GCG - 523 Gly/Ala 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 25/0 rpoB T508A or S531L or L511V, or H526R -
Valim A JCM 2000 TTG/TGG - 524 Leu/Trp 1996-1998 Brazil Sequencing RRDR MDR N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)" -
Zenteno-Cuevas R MemInstOswaldCruz 2009 TTG/TCG - 524 Leu/Ser 2007 Mexico Sequencing RRDR HR N.S. BACTEC 460 15/25 1/0 rpoB S531L -

rpoB disclaimer: All mutation coordinates are in reference to E. coli and not M. tuberculosis.

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator