Rv3795: embBRv0667: rpoB

Rv0667

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Rv0667: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Heep M AAC 2000 GTC/TTC - 146 Val/Phe Published 2003 Japan Sequencing Whole gene R 1-4, 8-32 ug/ml N.S. (6/6 || 3 high level of resistance / 6 total) (3/0) - -
Taniguchi H FEMS Micro 1996 GCG/GTG - 381 Ala/Val Published 1997 Japan Sequencing Whole gene R 200 ug/ml Proportion method, absolute concentration method 21/39 (1/0) - -
Cavusoglu C JCM 2002 CAG/CAT - 490 Gln/His Published 2002 Turkey Line probe assay, Sequencing RRDR R, RE, RHE, RH, RHES, RHS N.S. Proportion method 41/41 (1/0) - -
Schilke K IntJTubLungDis 1999 GAG/GCG - 504 Glu/Ala Published 1999 South Africa Sequencing RRDR MDR N.S. Not specified 105/105 (2/0) Double mutation with 531 -
Heym B Lancet 1994 TTC/TTG - 505 Phe /Leu 1991-1992 La Reunion PCR-SSCP - RSHE > 100 mg/L Proportion method 13/39 (2/0) "1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present" -
Stavrum R PlosOne 2009 TTC/TTA - 505 Phe /Leu Published 2009 India Sequencing Whole gene RSHE > 100 mg/L Proportion method 13/39 (2/0) "1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present" -
Wang Q JProtRes 2007 TTC/TCC - 505 Phe/Ser Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Bahrmand AR JCM 2009 GGC/AGC - 507 Gly/Ser 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR <50 ug/ml Proportion method 41/286 1/0 rpoB T508P -
Kim BJ JCM 1997 GGC/GAC - 507 Gly/Asp Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified. -
Bahrmand AR JCM 2009 GGC/GAT - 507 Gly/Asp 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB Q513STOP, H526Y, S531F -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del GGC ACC - 507-508 del Gly Thr - - - - - - - - - - -
Bahrmand AR JCM 2009 ACC/CAC - 508 Thr/His 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 6/0 rpoB H526Q, S531F -
Bahrmand AR JCM 2009 ACC/CCC - 508 Thr/Pro 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR <50 ug/ml Proportion method 41/286 4/0 rpoB G507S -
Bahrmand AR JCM 2009 ACC/GCC - 508 Thr/Ala 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR <75 ug/ml Proportion method 41/286 2/0 rpoB G523A -
Mani C JCM 2001 ACC/AGC - 508 Thr/Ser Published 2001 India Sequencing RRDR R >128ug/ml Proportion method 44/50 1/0 None described in the region sequenced. -
Matsiota-Bernard P JCM 1998 ACC/GCT - 508 Thr/Ser 1995-1996 Greece Line probe assay, Sequencing RRDR RHSEth N.S. Proportion method 17/17 1/0 None described in the region sequenced. -
Zenteno-Cuevas R MemInstOswaldCruz 2009 AGC/CAG - 509 Ser/Gln 2007 Mexico Sequencing RRDR HRSEZ N.S. BACTEC 460 15/25 1/0 None -
Williams D AAC 1994 AGC/ACC - 509 Ser/Thr Published 1994 Canada Sequencing RRDR RHES N.S. Proportion method 108/120 (1/0) Double mutation with 526 (Asp) -
Sekiguchi J JCM 2007 Jan AGC/AGG - 509 Ser/Arg Published 2007 Japan Sequencing RRDR R, MDR N.S. Proportion method, BACTEC 28/138 (0/1) - -
Zenteno-Cuevas R MemInstOswaldCruz 2009 CAG/AAG - 510 Gln/Lys 2007 Mexico Sequencing RRDR HREZ N.S. BACTEC 460 15/25 1/0 None -
Sajduda A JCM 2004 CAG/CAC - 510 Gln/His 2000 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (2/0) rpoB: double mutation with 516 GAC/TAC -
Kapur V JCM 1994 CTG/CCG - 511 Leu/Pro Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 4/0 "One of the strains was also Asp441Glu; another was Asp441Tyr; the third was also Ser437Thr."
Kapur V JCM 1994 CTG/CGG - 511 Leu/Arg Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced. -
Siddiqi N AAC 2002 CTG/GTG - 511 Leu/Val 1995-1998 India Sequencing RRDR R,O Not listed in Table Proportion method 94/126 (2/0) "1) rpoB dual mutation with N518T; gyrA S95T; 2) gyrA S95T" -
Kapur V JCM 1994 AGC/ACC - 512 Ser/Thr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 Also mutated at Leu436Pro. -
Sajduda A JCM 2004 AGC/ATC - 512 Ser/Ile 2001 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (1/0) rpoB: double mutation with 516 GAC/GGC -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 AGC/CGC - 512 Ser/Arg - - - - - - - - - - -
Chan RCY JAC 2007 AGC/GGC - 512 Ser/Gly 1994-2004 Hong Kong PCR-SSCP, Sequencing RRDR - - Absolute concentration method 250 221 - -
Bahrmand AR JCM 2009 CAA/TAA - 513 Gln/STOP 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB G507D, H526Y, S531F -
Bahrmand AR JCM 2009 CAA/AAT - 513 Gly/Asn 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB S512T, H526F, S531L -
Kapur V JCM 1994 CAA/CTA - 513 Gln/Leu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced.
Kapur V JCM 1994 CAA/AAA - 513 Gln/Lys Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced. -
Prammananan T CMI 2008 CAA/GAA - 513 Gln/Glu 2003-2005 Thailand Sequencing Whole gene R N.S. Proportion method, BACTEC 154/113 1/0 None described in the region sequenced. -
Kim BJ JCM 1997 CAA/CCA - 513 Gln/Pro Published 1997 South Korea Sequencing RRDR R N.S. Absolute concentration method. 32/58 2/0 Location of double mutants not specified. -
Valim A JCM 2000 CAA/CAC - 513 Gln/His - - - - - - - 82/100 1/0 - -
Secondary Publication: O'Sullivan DM JAntiChemo 2005 CAA/CGA - 513 Gln/Arg - - - - - - - - - - -
Kapur V JCM 1994 ins TTC - 513-514 ins Phe Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced. -
Kapur V JCM 1994 ins TTC ATG - 513-514 ins Phe Met Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del CAA TTC - 513-514 del Gln Phe - - - - - - - - - - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del AA TTC ATG G - 513-516 Gln/His and del Phe Met - - - - - - - - - - -
Valim A JCM 2000 del TTC - 514 del Phe 1996-1998 Brazil Sequencing RRDR RHSZEth N.S. Proportion method 82/100 (1/0) Same isolate had deletions: 515 (ATG-Met), 516(GAC-Asp) and change in codon 513 CAA(Gln)/CAC(His) -
Taniguchi H FEMS Micro 1996 TTC/TTG - 514 Phe/Leu Published 1996 Japan Sequencing Whole gene R 12.5 ug/ml Proportion method, absolute concentration method 21/39 (1/0) - -
Valim A JCM 2000 TTC/GTC - 514 Phe/Val 1996-1998 Brazil Sequencing RRDR RHSZEth N.S. Proportion method 82/100 (1/0) Same isolate had change in codon 531 TCG(Ser)/TTG(Leu) -
Cavusoglu C JCM 2002 ins CGG - 514-515 ins Arg Published 2002 Turkey Line probe assay, Sequencing RRDR R, RE, RHE, RH, RHES, RHS N.S. Proportion method 41/41 (1/0) - -
Lipin MY CMI 2007 del C AT - 514-515 Phe/Leu and del Met 1998-2001 Russia Sequencing RRDR RHS, RHSK, RHSE N.S. Absolute concentration method. 217/217 1/0 None described in the region sequenced. -
Valim A JCM 2000 del TTC ATG GAC - 514-516 del Phe Met Asp 1996-1998 Brazil Sequencing RRDR RHSZEth N.S. Proportion method 82/100 (1/0) Same isolate had change in codon 513 CAA(Gln)/CAC(His) -
Hillemann D Int J Tuberc Lung Dis 2005 ins TTC - 515 ins Phe 2004 Kazakhstan, Germany real-time sequencing FRET RRDR MDR N.S. N.S. 92/152 (1/0) - -
Sajduda A JCM 2004 ATG/ATT - 515 Met/Ile 2003 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (8/0) rpoB: double mutation with 516 GAC/TAC -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 ATG/ATA - 515 Met/Ile - - - - - - - - - - -
Valim A JCM 2000 del ATG GAC CAG AAC - 515-518 del Met Asp Gln Asn 1996-1998 Brazil Sequencing RRDR RHSEZEth N.S. Proportion method 82/100 (1/0) - -
Schilke K IntJTubLungDis 1999 GAC/AAC - 516 Asp/Asn Published 1999 South Africa Sequencing RRDR MDR N.S. N.S. 105/105 (1/0) - -
Bahrmand AR JCM 2009 GAC/CAC - 516 Asp/His 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR 50-75 ug/ml Proportion method 41/286 3/0 rpoB D516H, H526R -
Kapur V JCM 1994 GAC/GTC - 516 Asp/Val Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced.
Kapur V JCM 1994 GAC/GAG - 516 Asp/Glu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 Also mutated at Leu436Pro. -
Hillemann D Int J Tuberc Lung Dis 2005 GAC/GGC - 516 Asp/Gly 2004 Kazakhstan, Germany real-time sequencing FRET RRDR MDR N.S. N.S. 92/152 (1/0) - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 GAC/GCC - 516 Asp/Ala - - - - - - - - - - -
Sajduda A JCM 2004 GAC/GTG - 516 Asp/Val 2004 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (1/0) None -
Kapur V JCM 1994 GAC/TAC - 516 Asp/Tyr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 Also mutated at Leu436Pro.
Hillemann D Int J Tuberc Lung Dis 2005 GAC/TTC - 516 Asp/Phe 2004 Kazakhstan, Germany real-time sequencing FRET RRDR MDR N.S. N.S. 92/152 (1/0) - -
Kapur V JCM 1994 del GAC CAG - 516-517 del Asp Gln Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced. -
Xueqiong W MolBiotech 2009 GAC/CAC - 517 Gln/His 2002-2005 China Sequencing RRDR RSE N.S. Absolute concentration method 112/148 1/0 rpoB N518D -
Mani C JCM 2001 del GAC - 517 del Gln Published 2001 India Sequencing RRDR R >128ug/ml Proportion method 44/50 1/0 None described in the region sequenced. -
Sajduda A JCM 2004 CAA/CTA - 517 Gln/Leu 2005 Poland real-time sequencing FRET RRDR R, MDR N.S. BACTEC 460 64/113 (1/0) None -
Hillemann D AAC 2005 del CAG AAC - 517-518 del Gln Asn 2001 Germany real-time sequencing RRDR MDR N.S. - 103/113 (1/0) katG 315 AGC-ACC/Ser-Thr -
Kapur V JCM 1994 del CAG AAC - 517-518 del Gln Asn Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 None described in the region sequenced. -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 del G AAC AA - 517-519 Gln/His and del Asn Asn - - - - - - - - - - -
Wang Q JProtRes 2007 AAC/TAC - 518 Asn/Tyr Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Siddiqi N AAC 2002 AAC/ACC - 518 Asn/Thr 1995-1998 India Sequencing RRDR RHO, ROS, RO, RH N.S. Proportion method 94/126 (6/0) "1) rpoB dual mutaton with L511L; katG and inhA NM; gyrA A90A, S95T 3) rpoB dual mutation with R528P; gyrA S95T; rpsL NM; 4) rpoB dual mutaton with L511V; gyrA S95T; 5) gyrA S95T; 6) gyrA NM; 7) rpoB dual mutation with D516V; katG and inhA R463L" -
Hillemann D AAC 2005 AAC/ATC - 518 Asn/Ile 2001 Germany real-time sequencing RRDR MDR N.S. - 103/113 (1/0) None -
Kim BJ JCM 1997 AAC/CAC - 518 Asn/His Published 1997 South Korea Sequencing and PCR-SSCP RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified. -
Chan RCY JAC 2007 AAC/GAC - 518 Asn/Asp 1994-2004 Hong Kong PCR-SSCP, Sequencing RRDR - - Absolute concentration method. 250 221 - -
Bahrmand AR JCM 2009 AAC/AAG - 519 Asn/Lys 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR 50 ug/ml Proportion method 41/286 2/0 rpoB L511V, Q513E, H526R -
Heym B Lancet 1994 del AAC - 519 del Asn 1991-1992 Russia, Netherlands PCR-SSCP - MDR 10-100ug/ml Proportion method 13/39 (2/0) "1) katG mutation present; inhA no mutation present; 2) katG no mutation present" -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CTG/ATG - 521 Leu/Met - - - - - - - - - - -
Taniguchi H FEMS Micro 1996 CTG/CCG - 521 Leu/Pro Published 1998 Japan Sequencing Whole gene R < 0.39 ug/ml Proportion method, absolute concentration method 21/39 (0/1) - -
Secondary Publication: O'Sullivan DM JAntiChemo 2005 CTG/CTA - 521 Leu/Leu - - - - - - - - - - -
Bodmer T JAC 1995 TCG/TTG - 522 Ser/Leu Published 1998 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (1/0) -
Yuen LK JCM 1999 TCG/CAG - 522 Ser/Gln 1990-1997 Timor Sequencing RRDR RH 32-256 ug/ml Resistance ratio method, ,BACTEC 460, E-test 33/50 (2/0) None -
Secondary Publication: O'Sullivan DM JAntiChemo 2005 TCG/TGG - 522 Ser/Trp - - - - - - - - - - -
El Baghdadi J IJTLD 2003 CCC/ACC - 523 Gly/Trp 1996-2001 Morocco Sequencing RRDR RHS N.S. Resistance ratio method 101/122 (1/0) - -
Pozzi G JCM 1999 GGG/TGG - 523 Gly/Trp Published April 2000 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 8-128ug/ml Absolute concentration method 37/37 (1/0) Triple mutation with GAC516TAC and ACC525ATC -
Bahrmand AR JCM 2009 GGG/GCG - 523 Gly/Ala 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 25/0 rpoB T508A or S531L or L511V, or H526R -
Valim A JCM 2000 TTG/TGG - 524 Leu/Trp 1996-1998 Brazil Sequencing RRDR MDR N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)" -
Zenteno-Cuevas R MemInstOswaldCruz 2009 TTG/TCG - 524 Leu/Ser 2007 Mexico Sequencing RRDR HR N.S. BACTEC 460 15/25 1/0 rpoB S531L -
Valim A JCM 2000 ACC/CCC - 525 Thr/Pro 1996-1998 Brazil Sequencing RRDR MDR N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 526 CAC(His)/CTG(Leu); 527 del AAG(Lys)" -
Pozzi G JCM 1999 ACC/ATC - 525 Thr/Ile Published April 2001 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 8-128ug/ml Proportion method 37/37 (1/0) Triple mutation with GAC516TAC and GGG523TGG -
Bahrmand AR JCM 2009 CAC/TTC - 526 His/Phe 2005-2006 Iran Sequencing 411bp fragment of rpoB 41R, 37MDR >100 ug/ml Proportion method 41/286 2/0 rpoB S512T, G513N, S531L -
Ramaswamy SV J Med Micro 2004 CAC/AAC - 526 His/Asn 1996-2001 Mexico Sequencing - RHSE N.S. Proportion method 37/50 (1/0) "rpoB: Double mutation with 435 GAC/GAG; embB: 306 ATG/ATA1 "
Kapur V JCM 1994 CAC/GAC - 526 His/Asp Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 8/0 None described in the region sequenced.
Kapur V JCM 1994 CAC/TAC - 526 His/Tyr Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 39/0 None described in the region sequenced.
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/ACC - 526 His/Thr - - - - - - - - - - -
Prammananan T CMI 2008 CAC/AGC - 526 His/Ser 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 515 ATG/CTG -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 CAC/GGC - 526 His/Gly - - - - - - - - - - -
Kim BJ JCM 1997 CAC/TGC - 526 His/Cys Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 2/0 Location of double mutants not specified. -
Kim BJ JCM 1997 CAC/CGC - 526 His/Arg Published 1997 South Korea PCR-SSCP, Sequencing RRDR R N.S. Absolute concentration method. 32/58 1/0 Location of double mutants not specified.
Bodmer T JAC 1995 CAC/CCC - 526 His/Pro Published 2001 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (2/0) - -
Valim A JCM 2000 CAC/CTG - 526 His/Leu 1996-1998 Brazil Sequencing RRDR RHSEZEth N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 527 del AAG(Lys)" -
Sheng J JApplMicro 2008 CAC/CTT - 526 His/Leu 2002-2003 China PCR-SSCP , Sequencing RRDR R N.S. Agar proportion method 49/56 1/0 None in rpoB -
Kapur V JCM 1994 CAC/CTC - 526 His/Leu Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 2/0 None described in the region sequenced.
Kapur V JCM 1994 CAC/CAA - 526 His/Gln Published 1994 USA Sequencing Whole gene R N.S. Proportion method, BACTEC 121/128 1/0 Also mutated at Ser456Cys. -
Bodmer T JAC 1995 CAC/CAG - 526 His/Gln Published 2003 N.S. PCR-SSCP RRDR R >8ug/ml BACTEC 460 26/36 (2/0) Double mutation with 498 Val/Ala -
Siddiqi N AAC 2002 AAG/AAT - 527 Lys/Asn 1995-1998 India Sequencing RRDR HRH 40 ug/ml Proportion method 94/126 (2/0) "1) katG or inhA R463L; 2) katG or inhA R463L, rpoB dual mutation with L521L" -
Valim A JCM 2000 del AAG - 527 del Lys 1996-1998 Brazil Sequencing RRDR RHSEZEth N.S. Proportion method 82/100 (1/0) "Same isolate had changes in codons 524 TTG(Leu)/TGG(Trp); 525 ACC(Thr)/CCC(Pro); 526 CAC(His)/CTG(Leu)" -
Williams D AAC 1994 AAG/CAG - 527 Lys/Gln Published 1995 USA PCR-HDF, Sequencing RRDR RHEEt N.S. Proportion method 108/120 (1/0) Double mutation with 526 (His) -
Siddiqi N AAC 2002 CGC/CAC - 528 Arg/His 1995-1998 India Sequencing RRDR HR, ROS 64-128 ug/ml Proportion method 94/126 (2/0) "1) rpoB dual mutation with H526Y; gyrA S95T; rpsL NM; 2) rpoB 1 dual mutation with with S531W; katG and inhA R463L, Inh (C/T)" -
Siddiqi N AAC 2002 CGC/CCC - 528 Arg/Pro 1995-1998 India Sequencing RRDR ROS, RHO, RHS, RH 40-64 ug/ml* Proportion method 94/126 (4/0) "1) rpoB dual mutation with N518T; gyrA S95T; rpsL NM; 2) katG or inhA NA; gyrA S95T; 3) katG or inhA R463L; rpsL K121K; 4) katG or inhA R463L; rpoB dual mutation with H526Y" -
Zenteno-Cuevas R MemInstOswaldCruz 2009 CGC/CCT - 528 Arg/Pro 2007 Mexico Sequencing RRDR HRSEZ N.S. BACTEC 460 15/25 1/0 None -
Wang Q JProtRes 2007 TCG/TAG - 538 Leu/STOP Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCG/CAG - 531 Ser/Gln - - - - - - - - - - -
Donabella V Am J Respir Cell Mol Biol 1994 TCG/TTG - 531 Ser/Leu Published 1994 USA Sequencing RRDR R N.S. - (1/9) (1/0) -
Bodmer T JAC 1995 TCG/TGG - 531 Ser/Trp Published 2005 N.S. PCR-SSCP RRDR R 8ug/ml BACTEC 460 26/36 (1/0) -
Bodmer T JAC 1995 TCG/TAT - 531 Ser/Tyr Published 2006 N.S. PCR-SSCP RRDR R >8ug/ml BACTEC 460 26/36 (1/0) - -
Hillemann D AAC 2005 TCG/TTT - 531 Ser/Phe 2001 Germany real-time sequencing RRDR MDR N.S. - 103/113 (2/0) katG 315 AGC-ACC/Ser-Thr -
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 TCG/TGT - 531 Ser/Cys - - - - - - - - - - -
Moghazeh SL AAC 1996 CTG/CCG - 533 Leu/Pro 1992-1995 USA Sequencing N.S R >32ug/ml Proportion method 24/24 1/0 None described in the region sequenced.
Valim A JCM 2000 CTG/CCT - 533 Leu/Pro 1996-1998 Brazil Sequencing RRDR RH, RHS N.S. Proportion method 82/100 (2/0) Same isolate had double mutation: 526 CAC(His)/CTG(Leu) -
Tracevska T JCM 2002 CCC/TCC - 535 Pro/Ser 1999-2000 Latvia Line probe assay, Sequencing RRDR R, RH N.S. Absolute concentration method, BACTEC 51/70 (4/0) Double mutation with D516Y -
Prammananan T CMI 2008 CCC/CAC - 535 Pro/His 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 526 CAC/AGC His/Ser -
Wang Q JProtRes 2007 CTG/CCG - 538 Leu/Pro Published 1997 China Sequencing Whole gene R N.S. Proportion method, absolute concentration method 112/30 1/0 - -
Prammananan T CMI 2008 GAG/GGG - 541 Glu/Gly 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 526 CAC/TAC His/Tyr -
Pozzi G JCM 1999 GAG/GAT - 541 Glu/Gly Published 2002 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 32-128 ug/ml Proportion method 37/37 (1/0) Triple mutation with CAC526GAC and TCG553GCG -
Aslan G JpnJInfectDis 2008 CTG/ATG - 545 Leu/Met 2003-2006 Turkey Sequencing RRDR R or MDR N.S. BACTEC 460 19/41 3/0 rpoB S531A, katG S315T -
Pozzi G JCM 1999 TCG/GCG - 553 Ser/Ala Published 2003 Italy Sequencing RRDR RH, RHS, RHSCip, RHSAmi, RHSZ, RHSZAmi, RHSCZ 32-128 ug/ml Proportion method 37/37 (1/0) Triple mutation with CAC526GAC and GAG541GAT -
Ramaswamy SV J Med Micro 2004 ATC/GTC - 561 Ile/Val 1996-1998 Mexico Sequencing RRDR RHSE N.S. Proportion method 37/50 (1/0) "rpoB: Double mutation with 450 TCG/TTG; embB: 306 ATG/ATA" -
Heep M JCM 2001 ATC/ACC - 561 Ile/Thr 1997 Germany Sequencing RRDR N.S. N.S. Proportion method 111/111 (1/0) Double mutation with S456L -
Hauck Y JAC 2009 GAA/GGA - 562 Glu/Gly Published 2009 Various Sequencing RRDR R <1 ug/ml MGIT 960 122/122 1/0 rpoB P564L -
Hauck Y JAC 2009 CCT/CTT - 564 Pro/Leu Published 2009 Various Sequencing RRDR R <1 ug/ml MGIT 960 122/122 1/0 rpoB E562G -
Heep M JCM 2001 CTG/GTG - 571 Leu/Val 1997 Germany Sequencing RRDR RHEZ N.S. Proportion method 111/111 (2/0) Double mutation with D441Y -
Yuen LK JCM 1999 ATC/TTC - 572 Ile/Phe 1990-1997 Vietnam Sequencing RRDR RHE > 256 ug/ml Resistance ratio method, BACTEC 460, E-test 33/50 (1/0) None -
Chan RCY JAC 2007 TCG/TTG - 574 Ser/Leu 1994-2004 Hong Kong PCR-SSCP, Sequencing RRDR RHEZ >64 ug/ml Absolute concentration method. 221/250 1 katG 311 Asp/Gly -
Prammananan T CMI 2008 TCG/GCG - 622 Ser/Ala 2003-2005 Thailand Sequencing Whole gene MDR N.S. Proportion method 154/113 1/0 rpoB 531 TCG/TTG ser/Leu -
Heep M JCM 2001 CGC/TGC - 633 Arg/Cys 1997 Germany Sequencing RRDR RH N.S. Proportion method, BACTEC 460 111/111 (1/0) Double mutation with S456L -
Heep M JCM 2001 GAG/GAT - 672 Glu/Asp 1997 Germany Sequencing RRDR RH, RHE, RHZ, RHEZ N.S. Proportion method, BACTEC 460 111/111 (7/0) Double mutation with S456W -

rpoB disclaimer: All mutation coordinates are in reference to E. coli and not M. tuberculosis.

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator