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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: promoter region: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Marttila HJ AAC 1999 | T/G | -12 | -12 | - | 1994-1997 | Russia | Sequencing | Whole gene | Z | - | BACTEC 460 | 36/44 | 1/0 | not tested | - |
| Scorpio A AAC 1997 | A/C | -11 | -11 | - | 1992-1995 | - | PCR-SSCP | Whole gene | Z | >900ug/ml | Pzase testing by Wayne's method | 46/46 | 1/0 | - | - |
| Sreevatsan S AAC 1997 | A/G | -11 | -11 | - | 1996 | Diverse geographical locations | Sequencing | Whole gene | Z | - | BACTEC 460 | 67/118 | 2/0 | - |  |
| Morlock GP AAC 2000 | T/C | -7 | -7 | - | 1999 | - | Sequencing | Whole gene | Z | 100 | Proportion method | 37/60 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |