Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: high confidence mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Sreevatsan S AAC 1997 A/G -11 -11 - 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 -
Lemaitre N AAC 1999 GCG/CCG 7 3 Ala/Pro 1986 France Sequencing Whole gene ZHR 1000 - - 1/0 -
Hirano K TLD 1997 CAG/CCG 29 10 Gln/Pro 1997 Myanmar Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Scorpio A AAC 1997 GAC/GCC 35 12 Asp/Ala 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Scorpio A AAC 1997 TGC/CGC 40 14 Cys/Arg 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 TGC/CGC 40 14 Cys/His 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Hirano K TLD 1997 GGC/GAC 50 17 Gly/Asp 1997 Thailand Sequencing Whole gene ZHRS >800 Proportion method 33/168 2/0 -
Sreevatsan S AAC 1997 CTG/CCG 56 19 Leu/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Chan RCY JAC 2007 GTA/GGA 62 21 Val/Gly 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 -
Sreevatsan S AAC 1997 del G 70 24 Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 7/0 -
Hou L Epi Infect 2000 del G 71 24 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRH 600 Proportion method, BACTEC 460 35/65 1/0 -
Hirano K TLD 1997 TAC/TCC 101 34 Tyr/Ser 1997 Thailand Sequencing Whole gene ZHRSE >800 Proportion method 33/168 2/0 -
Louw GE Int J Tuberc Lung Dis 2006 CTG/CGG 104 35 Leu/Arg 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Sreevatsan S AAC 1997 TAC/TAG 123 41 Tyr/STOP 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Cheng SJ AAC 2000 GCA/GTA 137 46 Ala/Val - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 -
Sreevatsan S AAC 1997 ACC/GCC 139 47 Thr/Ala 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 11/0 -
Hirano K TLD 1997 CAC/CCC 152 51 His/Pro 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 -
Hirano K TLD 1997 CAC/CGC 152 51 His/Arg 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 -
Sreevatsan S AAC 1997 CCG/ACG 160 54 Pro/Thr 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 CAC/TAC 169 57 His/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Louw GE Int J Tuberc Lung Dis 2006 del T 172 58 Frameshift 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Hirano K TLD 1997 GAC/GGC 188 63 Asp/Gly 1997 Yemen Sequencing Whole gene ZHRS >800 Proportion method 33/168 1/0 -
Marttila HJ AAC 1999 TCG/CCG 196 66 Ser/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Hirano K TLD 1997 TCG/CCG 199 67 Ser/Pro 1997 Canada Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Lee KW J Korean Med Sci 2001 TGG/CGG 202 68 Trp/Arg 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Lee KW J Korean Med Sci 2001 TGG/GGG 202 68 Trp/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Sreevatsan S AAC 1997 TGG/TTG 203 68 Trp/Leu 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Morlock GP AAC 2000 CAT/CGT 212 71 His/Arg 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 -
Scorpio A AAC 1997 TGC/CGC 214 72 Cys/Arg 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Sreevatsan S AAC 1997 ACT/CCT 226 76 Thr/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Cheng SJ AAC 2000 CAT/CGT 245 82 His/Arg - USA Sequencing Whole gene ZHRES 300 Proportion method, BACTEC 460 59/59 1/0 -
Scorpio A AAC 1997 CTG/CCG 254 85 Leu/Pro 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 3/0 -
Scorpio A AAC 1997 AAG/AAT 288 96 Lys/Asn 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Cheng SJ AAC 2000 GGT/AGT 289 97 Gly/Ser - USA Sequencing Whole gene ZHRES >900 Proportion method, BACTEC 460 59/59 2/0 -
Morlock GP AAC 2000 TAC/TAG 297 99 Tyr/STOP 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 2/0 -
Marttila HJ AAC 1999 GCG/GTG 305 102 Ala/Val 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Marttila HJ AAC 1999 TAC/TAG 309 103 Tyr/STOP 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Hirano K TLD 1997 AGC/AGG 312 104 Ser/Arg 1997 Yemen Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Hirano K TLD 1997 ACG/CCG 340 114 Thr/Pro 1997 Yemen Sequencing Whole gene ZHR >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Marttila HJ AAC 1999 CTG/CGG 347 116 Leu/Arg 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Sreevatsan S AAC 1997 CGG/CCG 362 121 Arg/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Rodrigues V de F AAC 2005 GTC/GGC 384 128 Val/Gly 1998-2003 Brazil Sequencing Whole gene Z - Proportion method and Pzase test 59 40 -
Sreevatsan S AAC 1997 ins AGGTCGATG 388 - Ins Arg Ser Met 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 4/0 -
Hirano K TLD 1997 GTG/GGG 389 130 Val/Gly 1997 Canada Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Lee KW J Korean Med Sci 2001 ins GG 391 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Lemaitre N AAC 1999 ins GG 391 - Frameshift 1988 France Sequencing Whole gene ZHRES 500-1000 - 19/35 1/0 -
Escalante P TuberLung Dis 1998 GCC/GTC 401 134 Ala/Val 1995-1996 Peru Sequencing Whole gene ZHRP - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; "
Sreevatsan S AAC 1997 CAT/CGT 410 137 His/Arg 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 -
Scorpio A Nature Med 1996 TGT/TAT 413 138 Cys/Tyr - USA (Colorado) Sequencing Whole gene MDR >500ug/ml Pzase testing by Wayne's method 39910 1/0 -
Cheng SJ AAC 2000 GTG/ATG 415 139 Val/Met - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0? -
Morlock GP AAC 2000 GTG/CTG 415 139 Val/Leu 1999 - Sequencing Whole gene Z 100 Proportion method 37/60 1/0 -
Sreevatsan S AAC 1997 GTG/GCG 416 139 Val/Ala 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Cheng SJ AAC 2000 CGC/AGC 418 140 Arg/Ser - - Sequencing Whole gene Z - Proportion method, BACTEC 460 59/59 20/0 -
Scorpio A Nature Med 1996 CAG/CCG 422 141 Gln/Pro - USA Sequencing Whole gene MDR >500ug/ml Pzase testing by Wayne's method invitro 1/0 -
Scorpio A AAC 1997 ACG/AAG 425 142 Thr/Lys 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Cheng SJ AAC 2000 del 8bp 446 - Frameshift 1990-1992 Canada Sequencing Whole gene ZHRE >300 Proportion method, BACTEC 460 59/59 1/0 -
Lemaitre N AAC 1999 GTG/GGG 464 155 Val/Gly 1987 France Sequencing Whole gene ZHRE 1500 - 19/35 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 CTG/CCG 476 159 Leu/Pro 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Marttila HJ AAC 1999 ACA/CCA 478 160 Thr/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Marttila HJ AAC 1999 GCG/CCG 481 161 Ala/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Chan RCY JAC 2007 GGT/GAT 485 162 Gly/Asp 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene ZOREth 100mg/L BACTEC MGIT 960 89/250 1/0 "Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB)"
Rodrigues V de F AAC 2005 GCG/GAG 512 171 Ala/Glu 1998-2003 Brazil Sequencing Whole gene Z - Proportion method 59 40 -
Hirano K TLD 1997 CTG/CCG 515 172 Leu/Pro 1997 Canada Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 AGC/ACC 554 185 Ser/Thr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator