Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 95 to 99: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Peridgao J MDR 2008 TAC/TAA 285 95 Tyr/STOP 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Lee KW J Korean Med Sci 2001 AAG/CAG 286 96 Lys/Gln 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 AAG/GAG 286 96 Lys/Glu 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Scorpio A AAC 1997 AAG/ACG 287 96 Lys/Thr 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Hirano K TLD 1997 ins T 287 - Frameshift 1997 Canada Sequencing Whole gene ZHRS >800 Proportion method 33/168 1/0 - -
Lee KW J Korean Med Sci 2001 ins T 287 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 AAG/AAT 288 96 Lys/Asn 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Scorpio A Nature Med 1996 del G 288 - Frameshift - USA Sequencing Whole gene Z >500ug/ml PZase test with Wayne's method 39910 1/0 - -
Cheng SJ AAC 2000 GGT/AGT 289 97 Gly/Ser - USA Sequencing Whole gene ZHRES >900 Proportion method, BACTEC 460 59/59 2/0 -
Morlock GP AAC 2000 GGT/GAT 290 97 Gly/Asp 1999 - Sequencing Whole gene Z 400 Proportion method 37/60 1/0 - -
Hirano K TLD 1997 TAC/TAA 297 99 Tyr/STOP 1997 Thailand Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 - -
Morlock GP AAC 2000 TAC/TAG 297 99 Tyr/STOP 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 2/0 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator