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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 85 to 89: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Mestdagh M AAC 1999 | CTG/CGG | 254 | 85 | Leu/Arg | 1999 | Azerbaijan | Sequencing | Whole gene | Z | - | BACTEC 460 | 23/62 | 1/0 | - | - |
| Scorpio A AAC 1997 | CTG/CCG | 254 | 85 | Leu/Pro | 1992-1995 | - | PCR-SSCP | Whole gene | Z | >900ug/ml | Pzase testing by Wayne's method | 46/46 | 3/0 | - |  |
| Lemaitre N AAC 1999 | ACG/ATG | 260 | 87 | Thr/Met | 1987 | France | Sequencing | Whole gene | ZHRES | 1000-1500 | - | 19/35 | 1/0 | - | - |
| Hou L Epi Infect 2000 | TCG/TAG | 263 | 88 | Ser/STOP | 1996-1998 | China | PCR-SSCP | Whole gene | ZHRES | >2000 | Proportion method, BACTEC 460 | 35/65 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |