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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 80 to 84: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Brown TJ JMedMicro 2000 | del A | 239 | - | Frameshift | 2000 | Turkey | Sequencing | Whole gene | Z | - | BACTEC 460 | 13/18 | 1/0 | C2431T (rpoB) | - |
| Sachais BS MolDiag 1998 | TTC/GTC | 241 | 80 | Phe/Val | 1993-1999 | USA | Sequencing | Whole gene | Z | - | BACTEC at pH 6.4 | 39856 | 1/0 | - | - |
| Brown TJ JMedMicro 2000 | CAT/TAT Error? This makes Tyr not Asp. | 244 | 82 | His/Asp | 2000 | Turkey | Sequencing | Whole gene | ZHRP | - | BACTEC 460 | 13/18 | 1/0 | A2386T (rpoB) | - |
| Cheng SJ AAC 2000 | CAT/CGT | 245 | 82 | His/Arg | - | USA | Sequencing | Whole gene | ZHRES | 300 | Proportion method, BACTEC 460 | 59/59 | 1/0 | - |  |
| Rodrigues V de F AAC 2005 | CAT/CTT | 246 | 82 | His/Leu | 1998-2003 | Brazil | Sequencing | Whole gene | Z | - | Proportion method | 59 | 40 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |