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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 75 to 79: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Chan RCY JAC 2007 | ATG/ACG | 224 | 75 | Met/Thr | 1994-2004 | Hong Kong | PCR-SSCP , Sequencing | Whole gene | ZORH | 100ug/ml | BACTEC MGIT 960 | 89/250 | 1/0 | "Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB); Ser315Thr(katG)" | - |
| Sreevatsan S AAC 1997 | ACT/CCT | 226 | 76 | Thr/Pro | 1996 | Diverse geographical locations | Sequencing | Whole gene | Z | - | BACTEC 460 | 67/118 | 1/0 | - |  |
| Brown TJ JMedMicro 2000 | ACT/ATT | 227 | 76 | Thr/Ile | 2000 | United Kindom, Turkey | Sequencing | Whole gene | ZHRP | - | BACTEC 460 | 13/18 | 8/0 | C2431T (rpoB) | - |
| Morlock GP AAC 2000 | GGC/GAC | 233 | 78 | Gly/Asp | 1999 | - | Sequencing | Whole gene | Z | >800 | Proportion method | 37/60 | 1/0 | - | - |
| Chan RCY JAC 2007 | GCG/GGG | 236 | 79 | Ala/Gly | 1994-2004 | Hong Kong | PCR-SSCP , Sequencing | Whole gene | Z | - | BACTEC MGIT 960 | 250 | 89 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |