Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 70 to 74: 10 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Louw GE Int J Tuberc Lung Dis 2006 CAT/TAT 211 71 His/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Louw GE Int J Tuberc Lung Dis 2006 CAT/GAT 212 71 His/Asp 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Morlock GP AAC 2000 CAT/CGT 212 71 His/Arg 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 -
Cheng SJ AAC 2000 CAT/CAG 213 71 His/Glu - USA Sequencing Whole gene ZHRS >900 Proportion method, BACTEC 460 59/59 1/0 - -
Scorpio A AAC 1997 TGC/CGC 214 72 Cys/Arg 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 TGC/TAC 215 72 Cys/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Sekiguchi JI JCM 2007 TGC/TGG 216 72 Cys/Trp 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Lemaitre N AAC 1999 ins 29bp 215 - Frameshift 1986 France Sequencing Whole gene ZHRS >2000 - 19/35 1/0 - -
Sekiguchi JI JCM 2007 ins CGCATTGCCG 218 - Frameshift 2006 - Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Mestdagh M AAC 1999 ins G 221 74 Frameshift 1999 United Kingdom Sequencing Whole gene Z - BACTEC 460 23/62 2/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator