Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 65 to 69: 11 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Mestdagh M AAC 1999 del 68bp 195-263 - Frameshift 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Marttila HJ AAC 1999 TCG/CCG 196 66 Ser/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Hirano K TLD 1997 TCG/CCG 199 67 Ser/Pro 1997 Canada Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Lee KW J Korean Med Sci 2001 TGG/CGG 202 68 Trp/Arg 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Lee KW J Korean Med Sci 2001 TGG/GGG 202 68 Trp/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Cheng SJ AAC 2000 TGG/TCA 203 68 Trp/STOP - USA Sequencing Whole gene Z >900 Proportion method, BACTEC 460 59/59 1/0 - -
Lee KW J Korean Med Sci 2001 TGG/TCG 203 68 Trp/Ser 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Sreevatsan S AAC 1997 TGG/TTG 203 68 Trp/Leu 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Scorpio A AAC 1997 CCA/CGA 206 69 Pro/Arg 1992-1995 - PCR-SSCP Whole gene Z >300ug/ml Pzase testing by Wayne's method 46/46 2/0 - -
Hou L Epi Infect 2000 CCA/CGA 206 69 Pro/Arg 1996-1998 China PCR-SSCP Whole gene ZRHSE 1200 Proportion method, BACTEC 460 35/65 1/0 - -
Lemaitre N AAC 1999 CCA/CTA 206 69 Pro/Leu 1994 France Sequencing Whole gene ZHR (pH 5.6, 5.8) >2000/>2000 - 19/35 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator