Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv2043c: Codons 60 to 64: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Lemaitre N AAC 1999 ACA/CCA 181 61 Thr/Pro 1992 France Sequencing Whole gene ZHRES 500ug/ml - 19/35 1/0 - -
Mestdagh M AAC 1999 CCG/CAG?? 185 62 Pro/His 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Morlock GP AAC 2000 CCG/CGG 185 62 Pro/Arg 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Chan RCY JAC 2007 CCG/CTG 186 62 Pro/Leu 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Hirano K TLD 1997 GAC/GGC 188 63 Asp/Gly 1997 Yemen Sequencing Whole gene ZHRS >800 Proportion method 33/168 1/0 -
Scorpio A Nature Med 1996 GAC/CAC 187 63 Asp/His - USA (Colorado) Sequencing Whole gene MDR >500ug/ml PZase test with Wayne's method 39910 1/0 - -
Lee KW J Korean Med Sci 2001 TAT/GAT 190 64 Tyr/Asp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lemaitre N AAC 1999 ins A 192 64 Frameshift 1996 France Sequencing Whole gene ZSHE 1000ug/ml - - 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator