Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 5 to 9: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Scorpio A AAC 1997 ATC/AGC 14 5 Ile/Ser 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Escalante P TuberLung Dis 1998 GTC/ATC 19 7 Val/Ile 1995, 1996 Peru Sequencing Whole gene ZHRPES - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; " -
Escalante P TuberLung Dis 1998 GTC/TTC 19 7 Val/Phe 1995, 1996 Peru Sequencing Whole gene ZHRPS - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; embB, 328, GAT:A del" -
Hirano K TLD 1997 GTC/GGC 20 7 Val/Gly 1997 Yemen Sequencing Whole gene ZHRSE >800 Proportion method 33/168 2/0 - -
Lee KW J Korean Med Sci 2001 GTC/GAC 20 7 Val/Asp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 GAC/TAC 22 8 Asp/Tyr 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Lee KW J Korean Med Sci 2001 GAC/GGC 23 8 Asp/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 GAC/GAG 24 8 Asp/Glu 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Lee KW J Korean Med Sci 2001 GTG/GCG 26 9 Val/Ala 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lee KW J Korean Med Sci 2001 GTG/GGG 26 9 Val/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GTG/TTG 26 9 Val/Leu 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Chan RCY JAC 2007 GTG/TCG 27 9 Val/Ser 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator