Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 55 to 59: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Louw GE Int J Tuberc Lung Dis 2006 CAC/TAC 169 57 His/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Sreevatsan S AAC 1997 CAC/GAC 169 57 His/Asp 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 - -
Brown TJ JMedMicro 2000 CAC/CCC 170 57 His/Pro 2000 Turkey Sequencing Whole gene ZHRP - "BACTEC radiometric-based culture method, standard protocol; and PZase activity" 13/18 1/0 A2416T (rpoB) -
Chan RCY JAC 2007 CAC/CTC 170 57 His/Leu 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Louw GE Int J Tuberc Lung Dis 2006 del T 172 58 Frameshift 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Escalante P TuberLung Dis 1998 TTC/CTC 172 58 Phe/Leu 1995-1996 Peru Sequencing Whole gene ZHR - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 526 cac/ctc; embB, 306, ATG/ATA " -
Hirano K TLD 1997 TTC/TTG 174 58 Phe/Leu 1997 Canada Sequencing Whole gene ZHRS 400 Proportion method 33/168 1/0 - -
Brown TJ JMedMicro 2000 TCC/CCC 175 59 Ser/Pro 2000 Turkey Sequencing Whole gene ZHRP - BACTEC 460 13/18 1/0 C2431T (rpoB) -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator