Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 50 to 54: 15 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Rodrigues V de F AAC 2005 CAC/AAC 151 51 His/Asn 1998-2003 Brazil Sequencing Whole gene Z - Proportion method 59 40 - -
Mestdagh M AAC 1999 CAC/TAC 151 51 His/Tyr 1999 Scotland Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Lee KW J Korean Med Sci 2001 del 80bp 151-230 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hirano K TLD 1997 CAC/CCC 152 51 His/Pro 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 -
Hirano K TLD 1997 CAC/CGC 152 51 His/Arg 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 -
Sekiguchi JI JCM 2007 CAC/CAG 153 51 His/Gln 2006 Poland Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Sekiguchi JI JCM 2007 CAC/CAA 153 51 His/Gln 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 2/0 - -
Sekiguchi JI JCM 2007 GAC/AAC 151 53 Asp/Asn 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Cheng SJ AAC 2000 GAC/GCC 158 53 Asp/Ala - South korea Sequencing Whole gene Z >100 Proportion method, BACTEC 460 59/59 1/0 - -
Lee KW J Korean Med Sci 2001 del A 158 53 Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Sreevatsan S AAC 1997 CCG/ACG 160 54 Pro/Thr 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 CCG/CTG 161 54 Pro/Leu 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Lee KW J Korean Med Sci 2001 del C 161 54 Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 ins T 162 54 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Scorpio A Nature Med 1996 del G 162 54 Frameshift - USA Sequencing Whole gene MDR >500ug/ml "7H9 liquid medium, pH5.6; PZase activity assayed according to Wayne's method " 39910 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator