Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 45 to 49: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Lee KW J Korean Med Sci 2001 GTG/GGG 134 45 Val/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hirano K TLD 1997 ins G 136 46 Frameshift 1997 Yemen Sequencing Whole gene ZHE >800 Proportion method 33/168 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GCA/CCA 136 46 Ala/Pro 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Cheng SJ AAC 2000 GCA/GAA 137 46 Ala/Glu - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 - -
Cheng SJ AAC 2000 GCA/GTA 137 46 Ala/Val - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 -
Hou L Epi Infect 2000 ACC/CCC 139 47 Thr/Pro 1996-1998 China PCR-SSCP Whole gene ZRSE 1500 Proportion method, BACTEC 460 35/65 1/0 - -
Marttila HJ AAC 1999 ACC/TCC 139 47 Thr/Ser 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Sreevatsan S AAC 1997 ACC/GCC 139 47 Thr/Ala 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 11/0 -
Louw GE Int J Tuberc Lung Dis 2006 GAC/CAC 145 49 Asp/His 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Lee KW J Korean Med Sci 2001 GAC/GCC 146 49 Asp/Ala 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 GAC/GTC 146 49 Asp/Val 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Marttila HJ AAC 1999 GAC/GGC 146 49 Asp/Gly 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator