Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 35 to 39: 4 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Stavrum R PlosOne 2009 CTG/CCG 104 35 Leu/Pro Published 2009 India Sequencing Whole gene - - N.S. - 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 CTG/CGG 104 35 Leu/Arg 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Louw GE Int J Tuberc Lung Dis 2006 GGA/TAA 109-110 37 Glu/STOP 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Morlock GP AAC 2000 del 5.3kb 106 - Frameshift/Truncation 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator