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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 25 to 29: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Lee KW J Korean Med Sci 2001 | GCC/GAA | 74-75 | 25 | Ala/Glu | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 1/0 | - | - |
| Scorpio A AAC 1997 | GCG/GGG | 77 | 26 | Ala/Gly | 1992-1995 | - | PCR-SSCP | Whole gene | Z | >900ug/ml | Pzase testing by Wayne's method | 46/46 | 1/0 | - | - |
| Marttila HJ AAC 1999 | del C | 84 | 28 | Frameshift | 1994-1997 | Russia | Sequencing | Whole gene | Z | - | BACTEC 460 | 36/44 | 1/0 | not tested | - |
| Lee KW J Korean Med Sci 2001 | GCC/GAC | 83 | 28 | Ala/Asp | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 1/0 | - | - |
| Hannan MM JCM 2001 | del 24bp | 88-112 | - | Frameshift | 1996-1999 | California, USA | Sequencing | Whole gene | Z | - | BACTEC radiometric testing | 39883 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |