Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 20 to 24: 6 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Chan RCY JAC 2007 GTA/GGA 62 21 Val/Gly 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 -
Chan RCY JAC 2007 del A 64 22 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Hou L Epi Infect 2000 del C 59 20 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRSE 1800 Proportion method, BACTEC 460 35/65 1/0 - -
Lee KW J Korean Med Sci 2001 GGT/GTC 68-69 23 Gly/Val 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Sreevatsan S AAC 1997 del G 70 24 Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 7/0 -
Hou L Epi Infect 2000 del G 71 24 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRH 600 Proportion method, BACTEC 460 35/65 1/0 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator