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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 175 to 179: 3 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Sekiguchi JI JCM 2007 | ATG/GTG | 523 | 175 | Met/Val | 2006 | Japan | Multi-plex PCR | Whole gene | Z | - | Proportion method, rapid broth method | 17/138 | 1/0 | - | - |
| Lee KW J Korean Med Sci 2001 | ins C | 532 | - | Frameshift | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 1/0 | - | - |
| Louw GE Int J Tuberc Lung Dis 2006 | AGC/CGC | 535 | 179 | Ser/Arg | 2001-2002 | South Africa | Sequencing | Whole gene | ZHRSEthK | - | BACTEC MGIT 960 | 115 | 68 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |