Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

Return to gene list

Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv2043c: Codons 170 to 174: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Mestdagh M AAC 1999 GCG/ACG 511 171 Ala/Thr 1999 Bangladesh Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Sachais BS MolDiag 1998 GCG/CCG 511 171 Ala/Pro 1993-1999 USA Sequencing Whole gene Z - BACTEC at pH 6.4 39856 1/0 - -
Mestdagh M AAC 1999 GCG/GTG 512 171 Ala/Val 1999 Scotland Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Rodrigues V de F AAC 2005 GCG/GAG 512 171 Ala/Glu 1998-2003 Brazil Sequencing Whole gene Z - Proportion method 59 40 -
Mestdagh M AAC 1999 del C 512 - Frameshift 1999 Rwanda Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Hirano K TLD 1997 CTG/CCG 515 172 Leu/Pro 1997 Canada Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Mestdagh M AAC 1999 CTG/GCG 514-515 172 Leu/Ala 1999 Belgium Sequencing Whole gene Z - BACTEC 460 23/62 2/0 - -
Scorpio A AAC 1997 ins 5bp 518 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator