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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 160 to 164: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Marttila HJ AAC 1999 | ACA/CCA | 478 | 160 | Thr/Pro | 1994-1997 | Russia | Sequencing | Whole gene | Z | - | BACTEC 460 | 36/44 | 2/0 | not tested |  |
| Lee KW J Korean Med Sci 2001 | ins TGAC | 480 | - | Frameshift | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 1/0 | - | - |
| Marttila HJ AAC 1999 | GCG/CCG | 481 | 161 | Ala/Pro | 1994-1997 | Russia | Sequencing | Whole gene | Z | - | BACTEC 460 | 36/44 | 2/0 | not tested | |
| Chan RCY JAC 2007 | GGT/GAT | 485 | 162 | Gly/Asp | 1994-2004 | Hong Kong | PCR-SSCP , Sequencing | Whole gene | ZOREth | 100mg/L | BACTEC MGIT 960 | 89/250 | 1/0 | "Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB)" | |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |