Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 15 to 19: 6 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Chan RCY JAC 2007 del G 47 16 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Hirano K TLD 1997 GGC/GAC 50 17 Gly/Asp 1997 Thailand Sequencing Whole gene ZHRS >800 Proportion method 33/168 2/0 -
Chan RCY JAC 2007 GGC/GTC 50 17 Gly/Val 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Cheng SJ AAC 2000 ins GG 52 17 Frameshift - USA Sequencing Whole gene ZHR >900 Proportion method, BACTEC 460 59/59 1/0 - -
Chan RCY JAC 2007 CTG/CGG 56 19 Leu/Arg 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Sreevatsan S AAC 1997 CTG/CCG 56 19 Leu/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator