|
|
           
|
|
|
|
|
|
|
|
 
|
|
Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 155 to 159: 6 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Lemaitre N AAC 1999 | GTG/GGG | 464 | 155 | Val/Gly | 1987 | France | Sequencing | Whole gene | ZHRE | 1500 | - | 19/35 | 1/0 | - |  |
| Escalante P TuberLung Dis 1998 | GTG/GCG | 464 | 155 | Val/Ala | 1995, 1996 | Peru | Sequencing | Whole gene | ZHRES | - | Proportion method | 40146 | 1/0 | "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; " | - |
| Lee KW J Korean Med Sci 2001 | ins T | 465 | - | Frameshift | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 2/0 | - | - |
| Scorpio A AAC 1997 | del C | 475 | - | Frameshift | 1992-1995 | - | PCR-SSCP | Whole gene | Z | >900ug/ml | Pzase testing by Wayne's method | 46/46 | 1/0 | - | - |
| Louw GE Int J Tuberc Lung Dis 2006 | CTG/CCG | 476 | 159 | Leu/Pro | 2001-2002 | South Africa | Sequencing | Whole gene | ZHRSEthK | - | BACTEC MGIT 960 | 115 | 68 | - | |
| Lee KW J Korean Med Sci 2001 | CTG/CGG | 476 | 159 | Leu/Arg | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
|
© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |