Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 145 to 149: 9 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Lee KW J Korean Med Sci 2001 GCG/ACG 436 146 Ala/Thr 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lemaitre N AAC 1999 del G 436 - Frameshift 1987 France Sequencing Whole gene ZHRE 1000-1500 - 19/35 1/0 - -
Hirano K TLD 1997 GCG/GTG 437 146 Ala/Val 1997 India Sequencing Whole gene ZRS >800 Proportion method 33/168 1/0 - -
Peridgao J MDR 2008 ins CG 439 - Frameshift 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Sekiguchi JI JCM 2007 CGC/AGC 442 148 Arg/Ser 2006 Poland Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Brown TJ JMedMicro 2000 C/A 442 148 Arg/Ser 2000 Turkey Sequencing Whole gene ZHRP - BACTEC 460 13/18 1/0 C2431G(rpoB) -
Scorpio A AAC 1997 del G 443 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Cheng SJ AAC 2000 del 8bp 446 - Frameshift 1990-1992 Canada Sequencing Whole gene ZHRE >300 Proportion method, BACTEC 460 59/59 1/0 -
Scorpio A AAC 1997 ins 8bp 446 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator