Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 140 to 144: 11 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Cheng SJ AAC 2000 CGC/AGC 418 140 Arg/Ser - - Sequencing Whole gene Z - Proportion method, BACTEC 460 59/59 20/0 -
Lemaitre N AAC 1999 del 68bp 419 - Frameshift 1992 France Sequencing Whole gene ZHRE 1000 - 19/35 1/0 - -
Cheng SJ AAC 2000 ins G 420 - Frameshift - USA Sequencing Whole gene ZR >900 Proportion method, BACTEC 460 59/59 1/0 - -
Cheng SJ AAC 2000 ins GG 420 - Frameshift - USA Sequencing Whole gene ZHRSO >900 Proportion method, BACTEC 460 59/59 1/0 - -
Lee KW J Korean Med Sci 2001 CAG/TAG 421 141 Gln/STOP 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A Nature Med 1996 CAG/CCG 422 141 Gln/Pro - USA Sequencing Whole gene MDR >500ug/ml Pzase testing by Wayne's method invitro 1/0 -
Escalante P TuberLung Dis 1998 ACG/CCG 424 142 Thr/Pro 1995, 1996 Peru Sequencing Whole gene MDR - Proportion method 40146 1/0 rpoB, 516, GAC/TAC -
Hirano K TLD 1997 ACG/GCG 424 142 Thr/Ala 1997 Myanmar Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 - -
Scorpio A AAC 1997 ACG/AAG 425 142 Thr/Lys 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Scorpio A AAC 1997 ACG/ATG 425 142 Thr/Met 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Cheng SJ AAC 2000 ins GG 428 - Frameshift - South korea Sequencing Whole gene Z >100 Proportion method, BACTEC 460 59/59 1/0? - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator