Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 135 to 139: 17 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Morlock GP AAC 2000 ACC/CCC 403 135 Thr/Pro 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Lee KW J Korean Med Sci 2001 GAT/TAT 406 136 Asp/Tyr 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 2/0 - -
Lee KW J Korean Med Sci 2001 GAT/AAT 406 136 Asp/Asn 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Mestdagh M AAC 1999 GAT/CAT 406 136 Asp/His 1999 Scotland Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Lee KW J Korean Med Sci 2001 del G 406 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GAT/GGT 407 136 Asp/Gly 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Mestdagh M AAC 1999 ins C 407-408 - Frameshift 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Scorpio A AAC 1997 CAT/CCT 410 137 His/Pro 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Sreevatsan S AAC 1997 CAT/CGT 410 137 His/Arg 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 -
Cheng SJ AAC 2000 TGT/TCT 413 138 Cys/Ser - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0? - -
Scorpio A Nature Med 1996 TGT/TAT 413 138 Cys/Tyr - USA (Colorado) Sequencing Whole gene MDR >500ug/ml Pzase testing by Wayne's method 39910 1/0 -
Lee KW J Korean Med Sci 2001 ins G 414 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Cheng SJ AAC 2000 GTG/ATG 415 139 Val/Met - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0? -
Morlock GP AAC 2000 GTG/CTG 415 139 Val/Leu 1999 - Sequencing Whole gene Z 100 Proportion method 37/60 1/0 -
Morlock GP AAC 2000 GTG/GGG 416 139 Val/Gly 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Sreevatsan S AAC 1997 GTG/GCG 416 139 Val/Ala 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Scorpio A AAC 1997 del TG 416 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator