Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 130 to 134: 14 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Hirano K TLD 1997 GTG/GGG 389 130 Val/Gly 1997 Canada Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Lee KW J Korean Med Sci 2001 ins GG 391 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Lemaitre N AAC 1999 ins GG 391 - Frameshift 1988 France Sequencing Whole gene ZHRES 500-1000 - 19/35 1/0 -
Scorpio A AAC 1997 del G 391 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Lee KW J Korean Med Sci 2001 ins G 392 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hirano K TLD 1997 GGT/GAT 395 132 Gly/Asp 1997 Myanmar Sequencing Whole gene Z >800 Proportion method 33/168 1/0 - -
Scorpio A AAC 1997 GGT/AGT 394 132 Gly/Ser 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 2/0 - -
Hirano K TLD 1997 del 16bp 395-411 del - Frameshift 1997 India Sequencing Whole gene ZR >800 Proportion method 33/168 1/0 - -
Sreevatsan S AAC 1997 ins T 397 - Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 - -
Marttila HJ AAC 1999 ATT/ACT 398 133 Ile/Thr 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Morlock GP AAC 2000 ATT/AAT 398 133 Ile/Asn 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Escalante P TuberLung Dis 1998 GCC/GTC 401 134 Ala/Val 1995-1996 Peru Sequencing Whole gene ZHRP - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; "
Hou L Epi Infect 2000 ins CC 403 - Frameshift 1996-1998 China PCR-SSCP Whole gene ZRE 1000 Proportion method, BACTEC 460 35/65 1/0 - -
Sreevatsan S AAC 1997 ins C 403 - Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator