Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 125 to 129: 10 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Marttila HJ AAC 1999 GTC/GAC 374 125 Val/Asp 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Peridgao J MDR 2008 GTC/GGC 374 125 Val/Gly 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 19/0 - -
Marttila HJ AAC 1999 del 11bp 379-389 - Frameshift 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Lee KW J Korean Med Sci 2001 del GG 381 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Peridgao J MDR 2008 del 9bp 381 - Frameshift 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Lee KW J Korean Med Sci 2001 ins AG 382 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Rodrigues V de F AAC 2005 GTC/GGC 384 128 Val/Gly 1998-2003 Brazil Sequencing Whole gene Z - Proportion method and Pzase test 59 40 -
Lee KW J Korean Med Sci 2001 del ATGT 386-389 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Morlock GP AAC 2000 ins GAGGTCGAT 388 - ins Glu Val Asp 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Sreevatsan S AAC 1997 ins AGGTCGATG 388 - Ins Arg Ser Met 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 4/0 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator