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Rv2043c More about Rv2043c on TBDB.org More about Rv2043c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2043c: Codons 120 to 124: 4 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Portugal I AAC 2004 | CTG/CCG | 359 | 120 | Leu/Pro | 2000-2001 | Portugal | Sequencing | Whole gene | Z | - | BACTEC MGIT 960 | 55 | 55 | - | - |
| Sreevatsan S AAC 1997 | CGG/CCG | 362 | 121 | Arg/Pro | 1996 | Diverse geographical locations | Sequencing | Whole gene | Z | - | BACTEC 460 | 67/118 | 1/0 | - |  |
| Hou L Epi Infect 2000 | ins AG | 368 | - | Frameshift | 1996-1998 | China | PCR-SSCP | Whole gene | ZRHSE | 1000 | Proportion method, BACTEC 460 | 35/65 | 1/0 | - | - |
| Lee KW J Korean Med Sci 2001 | ins 18bp | 368 | - | Frameshift | 2001 | South korea | Sequencing | Whole gene | Z | - | PZase test with Wayne's method | 92/95 | 1/0 | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |