Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

Return to gene list

Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv2043c: Codons 115 to 119: 6 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Louw GE Int J Tuberc Lung Dis 2006 CTG/GTG 346 116 Leu/Val 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Marttila HJ AAC 1999 CTG/CGG 347 116 Leu/Arg 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Hou L Epi Infect 2000 AAT/ACT 353 118 Asn/Thr 1996-1998 China PCR-SSCP Whole gene ZHRS 1000 Proportion method, BACTEC 460 35/65 1/0 - -
Sreevatsan S AAC 1997 TGG/CGG 355 119 Trp/Arg 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 - -
Stavrum R PlosOne 2009 TGG/TGC 357 119 Trp/Cys Published 2009 India Sequencing Whole gene RSHE > 100 mg/L Proportion method 13/39 (2/0) "1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present" -
Lee KW J Korean Med Sci 2001 TGG/TGA 357 119 Trp/STOP 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator