Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv2043c: Codons 10 to 14: 12 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Scorpio A AAC 1997 del C 28 10 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Marttila HJ AAC 1999 CAA/AAA 28 10 Gln/Lys 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Marttila HJ AAC 1999 CAA/TAA 28 10 Gln/STOP 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Cheng SJ AAC 2000 CAG/CGA 29 10 Gln/Arg 1990-1992 USA Sequencing Whole gene ZHREO >900 Proportion method, BACTEC 460 59/59 1/0 - -
Hirano K TLD 1997 CAG/CCG 29 10 Gln/Pro 1997 Myanmar Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Morlock GP AAC 2000 CAG/CCA 29 10 Gln/Pro 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Scorpio A AAC 1997 GAC/AAC 34 12 Asp/Asn 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Scorpio A AAC 1997 GAC/GCC 35 12 Asp/Ala 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Lemaitre N AAC 1999 TTC/TCC 38 13 Phe/Ser 1987 France Sequencing Whole gene ZHRES >2000 - 19/35 1/0 - -
Scorpio A AAC 1997 TGC/CGC 40 14 Cys/Arg 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 TGC/CGC 40 14 Cys/His 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Lee KW J Korean Med Sci 2001 TGC/TAC 41 14 Cys/Tyr 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator