Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display high confidence mutations only
Rv2043c: Codons 100 to 104: 13 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Cheng SJ AAC 2000 ins G 301 - Frameshift - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 - -
Hou L Epi Infect 2000 ins A 301 - Frameshift 1996-1998 China PCR-SSCP Whole gene ZHRS 900 Proportion method, BACTEC 460 35/65 1/0 - -
Marttila HJ AAC 1999 GCG/ACG 304 102 Ala/Thr 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Marttila HJ AAC 1999 GCG/GTG 305 102 Ala/Val 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Lemaitre N AAC 1999 ins C 306 - Frameshift 1989 France Sequencing Whole gene ZHRES 500-1500 - 19/35 1/0 - -
Mestdagh M AAC 1999 TAC/CAC 307 103 Tyr/His 1999 Canada Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Lee KW J Korean Med Sci 2001 del TACAG 307 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lee KW J Korean Med Sci 2001 TAC/TCC 308 103 Tyr/Ser 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 2/0 - -
Lemaitre N AAC 1999 TAC/TGC 308 103 Tyr/Cys 1994 France Sequencing Whole gene ZHRE 1500 - - 1/0 - -
Marttila HJ AAC 1999 TAC/TAG 309 103 Tyr/STOP 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Morlock GP AAC 2000 TAC/TAA 309 103 Tyr/STOP 1999 - Sequencing Whole gene Z 100 Proportion method 37/60 1/0 - -
Scorpio A AAC 1997 del C 312 104 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Hirano K TLD 1997 AGC/AGG 312 104 Ser/Arg 1997 Yemen Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator