Rv2043c: pncA

Rv2043c

More about Rv2043c on    TBDB.org

More about Rv2043c on    TubercuList

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Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only
Rv2043c: Codons 0 to 4: 8 mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Hou L Epi Infect 2000 del 8bp 1 1 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRHSE >2000 Proportion method, BACTEC 460 35/65 1/0 - -
Scorpio A AAC 1997 del 11bp 1 1 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 2/0 - -
Portugal I AAC 2004 ATG/ACG 2 1 Met/Thr 2000-2001 Portugal Sequencing Whole gene Z - BACTEC MGIT 960 55 55 - -
Lee KW J Korean Med Sci 2001 ATG/ATT 3 1 Met/Ile 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lemaitre N AAC 1999 GCG/CCG 7 3 Ala/Pro 1986 France Sequencing Whole gene ZHR 1000 - - 1/0 -
Sekiguchi JI JCM 2007 GCG/GAG 8 3 Ala/Glu 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Lee KW J Korean Med Sci 2001 TTG/TGG 11 4 Leu/Trp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Morlock GP AAC 2000 TTG/TCG 11 4 Leu/Ser 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator