Rv2043c: pncA

Rv2043c

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Display high confidence mutations only
Rv2043c: all mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Marttila HJ AAC 1999 T/G -12 -12 - 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Scorpio A AAC 1997 A/C -11 -11 - 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Sreevatsan S AAC 1997 A/G -11 -11 - 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 -
Morlock GP AAC 2000 T/C -7 -7 - 1999 - Sequencing Whole gene Z 100 Proportion method 37/60 1/0 - -
Hou L Epi Infect 2000 del 8bp 1 1 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRHSE >2000 Proportion method, BACTEC 460 35/65 1/0 - -
Scorpio A AAC 1997 del 11bp 1 1 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 2/0 - -
Portugal I AAC 2004 ATG/ACG 2 1 Met/Thr 2000-2001 Portugal Sequencing Whole gene Z - BACTEC MGIT 960 55 55 - -
Lee KW J Korean Med Sci 2001 ATG/ATT 3 1 Met/Ile 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lemaitre N AAC 1999 GCG/CCG 7 3 Ala/Pro 1986 France Sequencing Whole gene ZHR 1000 - - 1/0 -
Sekiguchi JI JCM 2007 GCG/GAG 8 3 Ala/Glu 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Lee KW J Korean Med Sci 2001 TTG/TGG 11 4 Leu/Trp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Morlock GP AAC 2000 TTG/TCG 11 4 Leu/Ser 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Scorpio A AAC 1997 ATC/AGC 14 5 Ile/Ser 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Escalante P TuberLung Dis 1998 GTC/ATC 19 7 Val/Ile 1995, 1996 Peru Sequencing Whole gene ZHRPES - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; " -
Escalante P TuberLung Dis 1998 GTC/TTC 19 7 Val/Phe 1995, 1996 Peru Sequencing Whole gene ZHRPS - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; embB, 328, GAT:A del" -
Hirano K TLD 1997 GTC/GGC 20 7 Val/Gly 1997 Yemen Sequencing Whole gene ZHRSE >800 Proportion method 33/168 2/0 - -
Lee KW J Korean Med Sci 2001 GTC/GAC 20 7 Val/Asp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 GAC/TAC 22 8 Asp/Tyr 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Lee KW J Korean Med Sci 2001 GAC/GGC 23 8 Asp/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 GAC/GAG 24 8 Asp/Glu 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Lee KW J Korean Med Sci 2001 GTG/GCG 26 9 Val/Ala 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lee KW J Korean Med Sci 2001 GTG/GGG 26 9 Val/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GTG/TTG 26 9 Val/Leu 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Chan RCY JAC 2007 GTG/TCG 27 9 Val/Ser 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Scorpio A AAC 1997 del C 28 10 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Marttila HJ AAC 1999 CAA/AAA 28 10 Gln/Lys 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Marttila HJ AAC 1999 CAA/TAA 28 10 Gln/STOP 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Cheng SJ AAC 2000 CAG/CGA 29 10 Gln/Arg 1990-1992 USA Sequencing Whole gene ZHREO >900 Proportion method, BACTEC 460 59/59 1/0 - -
Hirano K TLD 1997 CAG/CCG 29 10 Gln/Pro 1997 Myanmar Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Morlock GP AAC 2000 CAG/CCA 29 10 Gln/Pro 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Scorpio A AAC 1997 GAC/AAC 34 12 Asp/Asn 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Scorpio A AAC 1997 GAC/GCC 35 12 Asp/Ala 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Lemaitre N AAC 1999 TTC/TCC 38 13 Phe/Ser 1987 France Sequencing Whole gene ZHRES >2000 - 19/35 1/0 - -
Scorpio A AAC 1997 TGC/CGC 40 14 Cys/Arg 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 TGC/CGC 40 14 Cys/His 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Lee KW J Korean Med Sci 2001 TGC/TAC 41 14 Cys/Tyr 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Chan RCY JAC 2007 del G 47 16 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Hirano K TLD 1997 GGC/GAC 50 17 Gly/Asp 1997 Thailand Sequencing Whole gene ZHRS >800 Proportion method 33/168 2/0 -
Chan RCY JAC 2007 GGC/GTC 50 17 Gly/Val 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Cheng SJ AAC 2000 ins GG 52 17 Frameshift - USA Sequencing Whole gene ZHR >900 Proportion method, BACTEC 460 59/59 1/0 - -
Chan RCY JAC 2007 CTG/CGG 56 19 Leu/Arg 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Sreevatsan S AAC 1997 CTG/CCG 56 19 Leu/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Chan RCY JAC 2007 GTA/GGA 62 21 Val/Gly 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 -
Chan RCY JAC 2007 del A 64 22 Frameshift 1994-2004 Hong Kong PCR-SSCP, Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Hou L Epi Infect 2000 del C 59 20 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRSE 1800 Proportion method, BACTEC 460 35/65 1/0 - -
Lee KW J Korean Med Sci 2001 GGT/GTC 68-69 23 Gly/Val 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Sreevatsan S AAC 1997 del G 70 24 Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 7/0 -
Hou L Epi Infect 2000 del G 71 24 Frameshift 1996-1998 China PCR-SSCP Whole gene ZRH 600 Proportion method, BACTEC 460 35/65 1/0 -
Lee KW J Korean Med Sci 2001 GCC/GAA 74-75 25 Ala/Glu 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 GCG/GGG 77 26 Ala/Gly 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Marttila HJ AAC 1999 del C 84 28 Frameshift 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Lee KW J Korean Med Sci 2001 GCC/GAC 83 28 Ala/Asp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hannan MM JCM 2001 del 24bp 88-112 - Frameshift 1996-1999 California, USA Sequencing Whole gene Z - BACTEC radiometric testing 39883 1/0 - -
Scorpio A AAC 1997 del 118bp 98-216 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Scorpio A AAC 1997 ins T 100 34 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Hirano K TLD 1997 TAC/TCC 101 34 Tyr/Ser 1997 Thailand Sequencing Whole gene ZHRSE >800 Proportion method 33/168 2/0 -
Stavrum R PlosOne 2009 CTG/CCG 104 35 Leu/Pro Published 2009 India Sequencing Whole gene - - N.S. - 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 CTG/CGG 104 35 Leu/Arg 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Louw GE Int J Tuberc Lung Dis 2006 GGA/TAA 109-110 37 Glu/STOP 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Morlock GP AAC 2000 del 5.3kb 106 - Frameshift/Truncation 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Hou L Epi Infect 2000 TAC/CAC 121 41 Tyr/His 1996-1998 China PCR-SSCP Whole gene ZHRE 600 Proportion method, BACTEC 460 35/65 1/0 - -
Hirano K TLD 1997 TAC/TAA 123 41 Tyr/STOP 1997 Thailand Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 - -
Sreevatsan S AAC 1997 TAC/TAG 123 41 Tyr/STOP 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Hirano K TLD 1997 CAC/CCC 128 43 His/Pro 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 - -
Lee KW J Korean Med Sci 2001 GTG/GGG 134 45 Val/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hirano K TLD 1997 ins G 136 46 Frameshift 1997 Yemen Sequencing Whole gene ZHE >800 Proportion method 33/168 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GCA/CCA 136 46 Ala/Pro 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Cheng SJ AAC 2000 GCA/GAA 137 46 Ala/Glu - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 - -
Cheng SJ AAC 2000 GCA/GTA 137 46 Ala/Val - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 -
Hou L Epi Infect 2000 ACC/CCC 139 47 Thr/Pro 1996-1998 China PCR-SSCP Whole gene ZRSE 1500 Proportion method, BACTEC 460 35/65 1/0 - -
Marttila HJ AAC 1999 ACC/TCC 139 47 Thr/Ser 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Sreevatsan S AAC 1997 ACC/GCC 139 47 Thr/Ala 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 11/0 -
Louw GE Int J Tuberc Lung Dis 2006 GAC/CAC 145 49 Asp/His 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Lee KW J Korean Med Sci 2001 GAC/GCC 146 49 Asp/Ala 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 GAC/GTC 146 49 Asp/Val 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Marttila HJ AAC 1999 GAC/GGC 146 49 Asp/Gly 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Rodrigues V de F AAC 2005 CAC/AAC 151 51 His/Asn 1998-2003 Brazil Sequencing Whole gene Z - Proportion method 59 40 - -
Mestdagh M AAC 1999 CAC/TAC 151 51 His/Tyr 1999 Scotland Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Lee KW J Korean Med Sci 2001 del 80bp 151-230 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hirano K TLD 1997 CAC/CCC 152 51 His/Pro 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 -
Hirano K TLD 1997 CAC/CGC 152 51 His/Arg 1997 Thailand Sequencing Whole gene ZHR >800 Proportion method 33/168 1/0 -
Sekiguchi JI JCM 2007 CAC/CAG 153 51 His/Gln 2006 Poland Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Sekiguchi JI JCM 2007 CAC/CAA 153 51 His/Gln 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 2/0 - -
Sekiguchi JI JCM 2007 GAC/AAC 151 53 Asp/Asn 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Cheng SJ AAC 2000 GAC/GCC 158 53 Asp/Ala - South korea Sequencing Whole gene Z >100 Proportion method, BACTEC 460 59/59 1/0 - -
Lee KW J Korean Med Sci 2001 del A 158 53 Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Sreevatsan S AAC 1997 CCG/ACG 160 54 Pro/Thr 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 CCG/CTG 161 54 Pro/Leu 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Lee KW J Korean Med Sci 2001 del C 161 54 Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 ins T 162 54 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Scorpio A Nature Med 1996 del G 162 54 Frameshift - USA Sequencing Whole gene MDR >500ug/ml "7H9 liquid medium, pH5.6; PZase activity assayed according to Wayne's method " 39910 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 CAC/TAC 169 57 His/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Sreevatsan S AAC 1997 CAC/GAC 169 57 His/Asp 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 - -
Brown TJ JMedMicro 2000 CAC/CCC 170 57 His/Pro 2000 Turkey Sequencing Whole gene ZHRP - "BACTEC radiometric-based culture method, standard protocol; and PZase activity" 13/18 1/0 A2416T (rpoB) -
Chan RCY JAC 2007 CAC/CTC 170 57 His/Leu 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Louw GE Int J Tuberc Lung Dis 2006 del T 172 58 Frameshift 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Escalante P TuberLung Dis 1998 TTC/CTC 172 58 Phe/Leu 1995-1996 Peru Sequencing Whole gene ZHR - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 526 cac/ctc; embB, 306, ATG/ATA " -
Hirano K TLD 1997 TTC/TTG 174 58 Phe/Leu 1997 Canada Sequencing Whole gene ZHRS 400 Proportion method 33/168 1/0 - -
Brown TJ JMedMicro 2000 TCC/CCC 175 59 Ser/Pro 2000 Turkey Sequencing Whole gene ZHRP - BACTEC 460 13/18 1/0 C2431T (rpoB) -
Lemaitre N AAC 1999 ACA/CCA 181 61 Thr/Pro 1992 France Sequencing Whole gene ZHRES 500ug/ml - 19/35 1/0 - -
Mestdagh M AAC 1999 CCG/CAG?? 185 62 Pro/His 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Morlock GP AAC 2000 CCG/CGG 185 62 Pro/Arg 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Chan RCY JAC 2007 CCG/CTG 186 62 Pro/Leu 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Hirano K TLD 1997 GAC/GGC 188 63 Asp/Gly 1997 Yemen Sequencing Whole gene ZHRS >800 Proportion method 33/168 1/0 -
Scorpio A Nature Med 1996 GAC/CAC 187 63 Asp/His - USA (Colorado) Sequencing Whole gene MDR >500ug/ml PZase test with Wayne's method 39910 1/0 - -
Lee KW J Korean Med Sci 2001 TAT/GAT 190 64 Tyr/Asp 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lemaitre N AAC 1999 ins A 192 64 Frameshift 1996 France Sequencing Whole gene ZSHE 1000ug/ml - - 1/0 - -
Mestdagh M AAC 1999 del 68bp 195-263 - Frameshift 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Marttila HJ AAC 1999 TCG/CCG 196 66 Ser/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Hirano K TLD 1997 TCG/CCG 199 67 Ser/Pro 1997 Canada Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Lee KW J Korean Med Sci 2001 TGG/CGG 202 68 Trp/Arg 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Lee KW J Korean Med Sci 2001 TGG/GGG 202 68 Trp/Gly 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Cheng SJ AAC 2000 TGG/TCA 203 68 Trp/STOP - USA Sequencing Whole gene Z >900 Proportion method, BACTEC 460 59/59 1/0 - -
Lee KW J Korean Med Sci 2001 TGG/TCG 203 68 Trp/Ser 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Sreevatsan S AAC 1997 TGG/TTG 203 68 Trp/Leu 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Scorpio A AAC 1997 CCA/CGA 206 69 Pro/Arg 1992-1995 - PCR-SSCP Whole gene Z >300ug/ml Pzase testing by Wayne's method 46/46 2/0 - -
Hou L Epi Infect 2000 CCA/CGA 206 69 Pro/Arg 1996-1998 China PCR-SSCP Whole gene ZRHSE 1200 Proportion method, BACTEC 460 35/65 1/0 - -
Lemaitre N AAC 1999 CCA/CTA 206 69 Pro/Leu 1994 France Sequencing Whole gene ZHR (pH 5.6, 5.8) >2000/>2000 - 19/35 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 CAT/TAT 211 71 His/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Louw GE Int J Tuberc Lung Dis 2006 CAT/GAT 212 71 His/Asp 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Morlock GP AAC 2000 CAT/CGT 212 71 His/Arg 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 -
Cheng SJ AAC 2000 CAT/CAG 213 71 His/Glu - USA Sequencing Whole gene ZHRS >900 Proportion method, BACTEC 460 59/59 1/0 - -
Scorpio A AAC 1997 TGC/CGC 214 72 Cys/Arg 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 TGC/TAC 215 72 Cys/Tyr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Sekiguchi JI JCM 2007 TGC/TGG 216 72 Cys/Trp 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Lemaitre N AAC 1999 ins 29bp 215 - Frameshift 1986 France Sequencing Whole gene ZHRS >2000 - 19/35 1/0 - -
Sekiguchi JI JCM 2007 ins CGCATTGCCG 218 - Frameshift 2006 - Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Mestdagh M AAC 1999 ins G 221 74 Frameshift 1999 United Kingdom Sequencing Whole gene Z - BACTEC 460 23/62 2/0 - -
Chan RCY JAC 2007 ATG/ACG 224 75 Met/Thr 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene ZORH 100ug/ml BACTEC MGIT 960 89/250 1/0 "Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB); Ser315Thr(katG)" -
Sreevatsan S AAC 1997 ACT/CCT 226 76 Thr/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Brown TJ JMedMicro 2000 ACT/ATT 227 76 Thr/Ile 2000 United Kindom, Turkey Sequencing Whole gene ZHRP - BACTEC 460 13/18 8/0 C2431T (rpoB) -
Morlock GP AAC 2000 GGC/GAC 233 78 Gly/Asp 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Chan RCY JAC 2007 GCG/GGG 236 79 Ala/Gly 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene Z - BACTEC MGIT 960 250 89 - -
Brown TJ JMedMicro 2000 del A 239 - Frameshift 2000 Turkey Sequencing Whole gene Z - BACTEC 460 13/18 1/0 C2431T (rpoB) -
Sachais BS MolDiag 1998 TTC/GTC 241 80 Phe/Val 1993-1999 USA Sequencing Whole gene Z - BACTEC at pH 6.4 39856 1/0 - -
Brown TJ JMedMicro 2000 CAT/TAT Error? This makes Tyr not Asp. 244 82 His/Asp 2000 Turkey Sequencing Whole gene ZHRP - BACTEC 460 13/18 1/0 A2386T (rpoB) -
Cheng SJ AAC 2000 CAT/CGT 245 82 His/Arg - USA Sequencing Whole gene ZHRES 300 Proportion method, BACTEC 460 59/59 1/0 -
Rodrigues V de F AAC 2005 CAT/CTT 246 82 His/Leu 1998-2003 Brazil Sequencing Whole gene Z - Proportion method 59 40 - -
Peridgao J MDR 2008 ins C 250 - Frameshift 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 3/0 - -
Mestdagh M AAC 1999 CTG/CGG 254 85 Leu/Arg 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Scorpio A AAC 1997 CTG/CCG 254 85 Leu/Pro 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 3/0 -
Lemaitre N AAC 1999 ACG/ATG 260 87 Thr/Met 1987 France Sequencing Whole gene ZHRES 1000-1500 - 19/35 1/0 - -
Hou L Epi Infect 2000 TCG/TAG 263 88 Ser/STOP 1996-1998 China PCR-SSCP Whole gene ZHRES >2000 Proportion method, BACTEC 460 35/65 1/0 - -
Hannan MM JCM 2001 ATC/AGC 269 90 Ile/Ser 1996-1999 USA Sequencing Whole gene Z - BACTEC radiometric testing 39883 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 ATC/AGC 269 90 Ile/Ser 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Sreevatsan S AAC 1997 TTC/CCC 280 94 Phe/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 T281C -
Peridgao J MDR 2008 ins T 282 - Frameshift 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Peridgao J MDR 2008 TAC/TAA 285 95 Tyr/STOP 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Lee KW J Korean Med Sci 2001 AAG/CAG 286 96 Lys/Gln 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 AAG/GAG 286 96 Lys/Glu 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Scorpio A AAC 1997 AAG/ACG 287 96 Lys/Thr 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Hirano K TLD 1997 ins T 287 - Frameshift 1997 Canada Sequencing Whole gene ZHRS >800 Proportion method 33/168 1/0 - -
Lee KW J Korean Med Sci 2001 ins T 287 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A AAC 1997 AAG/AAT 288 96 Lys/Asn 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Scorpio A Nature Med 1996 del G 288 - Frameshift - USA Sequencing Whole gene Z >500ug/ml PZase test with Wayne's method 39910 1/0 - -
Cheng SJ AAC 2000 GGT/AGT 289 97 Gly/Ser - USA Sequencing Whole gene ZHRES >900 Proportion method, BACTEC 460 59/59 2/0 -
Morlock GP AAC 2000 GGT/GAT 290 97 Gly/Asp 1999 - Sequencing Whole gene Z 400 Proportion method 37/60 1/0 - -
Hirano K TLD 1997 TAC/TAA 297 99 Tyr/STOP 1997 Thailand Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 - -
Morlock GP AAC 2000 TAC/TAG 297 99 Tyr/STOP 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 2/0 -
Cheng SJ AAC 2000 ins G 301 - Frameshift - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0 - -
Hou L Epi Infect 2000 ins A 301 - Frameshift 1996-1998 China PCR-SSCP Whole gene ZHRS 900 Proportion method, BACTEC 460 35/65 1/0 - -
Marttila HJ AAC 1999 GCG/ACG 304 102 Ala/Thr 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Marttila HJ AAC 1999 GCG/GTG 305 102 Ala/Val 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Lemaitre N AAC 1999 ins C 306 - Frameshift 1989 France Sequencing Whole gene ZHRES 500-1500 - 19/35 1/0 - -
Mestdagh M AAC 1999 TAC/CAC 307 103 Tyr/His 1999 Canada Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Lee KW J Korean Med Sci 2001 del TACAG 307 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lee KW J Korean Med Sci 2001 TAC/TCC 308 103 Tyr/Ser 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 2/0 - -
Lemaitre N AAC 1999 TAC/TGC 308 103 Tyr/Cys 1994 France Sequencing Whole gene ZHRE 1500 - - 1/0 - -
Marttila HJ AAC 1999 TAC/TAG 309 103 Tyr/STOP 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Morlock GP AAC 2000 TAC/TAA 309 103 Tyr/STOP 1999 - Sequencing Whole gene Z 100 Proportion method 37/60 1/0 - -
Scorpio A AAC 1997 del C 312 104 Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Hirano K TLD 1997 AGC/AGG 312 104 Ser/Arg 1997 Yemen Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Louw GE Int J Tuberc Lung Dis 2006 GAA/AAA 319 107 Gly/Lys 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Hirano K TLD 1997 ACG/CCG 340 114 Thr/Pro 1997 Yemen Sequencing Whole gene ZHR >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Cheng SJ AAC 2000 del C 341 - Frameshift - South Korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0? - -
Lemaitre N AAC 1999 ins 1355bp 341 - Frameshift 1989 France Sequencing Whole gene ZHRE 1000 - 19/35 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 CTG/GTG 346 116 Leu/Val 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Marttila HJ AAC 1999 CTG/CGG 347 116 Leu/Arg 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested
Hou L Epi Infect 2000 AAT/ACT 353 118 Asn/Thr 1996-1998 China PCR-SSCP Whole gene ZHRS 1000 Proportion method, BACTEC 460 35/65 1/0 - -
Sreevatsan S AAC 1997 TGG/CGG 355 119 Trp/Arg 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 - -
Stavrum R PlosOne 2009 TGG/TGC 357 119 Trp/Cys Published 2009 India Sequencing Whole gene RSHE > 100 mg/L Proportion method 13/39 (2/0) "1) rpoB L511P; S531C; rpsL K42R; katG no mutation; inhA mutation present 2) rpoB L511P; S531C; rpsL K42R; katG mutation present; inhA mutation present" -
Lee KW J Korean Med Sci 2001 TGG/TGA 357 119 Trp/STOP 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Portugal I AAC 2004 CTG/CCG 359 120 Leu/Pro 2000-2001 Portugal Sequencing Whole gene Z - BACTEC MGIT 960 55 55 - -
Sreevatsan S AAC 1997 CGG/CCG 362 121 Arg/Pro 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Hou L Epi Infect 2000 ins AG 368 - Frameshift 1996-1998 China PCR-SSCP Whole gene ZRHSE 1000 Proportion method, BACTEC 460 35/65 1/0 - -
Lee KW J Korean Med Sci 2001 ins 18bp 368 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 GTC/GAC 374 125 Val/Asp 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Peridgao J MDR 2008 GTC/GGC 374 125 Val/Gly 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 19/0 - -
Marttila HJ AAC 1999 del 11bp 379-389 - Frameshift 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Lee KW J Korean Med Sci 2001 del GG 381 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Peridgao J MDR 2008 del 9bp 381 - Frameshift 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Lee KW J Korean Med Sci 2001 ins AG 382 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Rodrigues V de F AAC 2005 GTC/GGC 384 128 Val/Gly 1998-2003 Brazil Sequencing Whole gene Z - Proportion method and Pzase test 59 40 -
Lee KW J Korean Med Sci 2001 del ATGT 386-389 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Morlock GP AAC 2000 ins GAGGTCGAT 388 - ins Glu Val Asp 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Sreevatsan S AAC 1997 ins AGGTCGATG 388 - Ins Arg Ser Met 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 4/0 -
Hirano K TLD 1997 GTG/GGG 389 130 Val/Gly 1997 Canada Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 -
Lee KW J Korean Med Sci 2001 ins GG 391 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 -
Lemaitre N AAC 1999 ins GG 391 - Frameshift 1988 France Sequencing Whole gene ZHRES 500-1000 - 19/35 1/0 -
Scorpio A AAC 1997 del G 391 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Lee KW J Korean Med Sci 2001 ins G 392 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Hirano K TLD 1997 GGT/GAT 395 132 Gly/Asp 1997 Myanmar Sequencing Whole gene Z >800 Proportion method 33/168 1/0 - -
Scorpio A AAC 1997 GGT/AGT 394 132 Gly/Ser 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 2/0 - -
Hirano K TLD 1997 del 16bp 395-411 del - Frameshift 1997 India Sequencing Whole gene ZR >800 Proportion method 33/168 1/0 - -
Sreevatsan S AAC 1997 ins T 397 - Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 - -
Marttila HJ AAC 1999 ATT/ACT 398 133 Ile/Thr 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Morlock GP AAC 2000 ATT/AAT 398 133 Ile/Asn 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Escalante P TuberLung Dis 1998 GCC/GTC 401 134 Ala/Val 1995-1996 Peru Sequencing Whole gene ZHRP - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; "
Morlock GP AAC 2000 ACC/CCC 403 135 Thr/Pro 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Hou L Epi Infect 2000 ins CC 403 - Frameshift 1996-1998 China PCR-SSCP Whole gene ZRE 1000 Proportion method, BACTEC 460 35/65 1/0 - -
Sreevatsan S AAC 1997 ins C 403 - Frameshift 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 - -
Lee KW J Korean Med Sci 2001 GAT/TAT 406 136 Asp/Tyr 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 2/0 - -
Lee KW J Korean Med Sci 2001 GAT/AAT 406 136 Asp/Asn 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Mestdagh M AAC 1999 GAT/CAT 406 136 Asp/His 1999 Scotland Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Lee KW J Korean Med Sci 2001 del G 406 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GAT/GGT 407 136 Asp/Gly 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Mestdagh M AAC 1999 ins C 407-408 - Frameshift 1999 Azerbaijan Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Scorpio A AAC 1997 CAT/CCT 410 137 His/Pro 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Sreevatsan S AAC 1997 CAT/CGT 410 137 His/Arg 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 2/0 -
Cheng SJ AAC 2000 TGT/TCT 413 138 Cys/Ser - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0? - -
Scorpio A Nature Med 1996 TGT/TAT 413 138 Cys/Tyr - USA (Colorado) Sequencing Whole gene MDR >500ug/ml Pzase testing by Wayne's method 39910 1/0 -
Lee KW J Korean Med Sci 2001 ins G 414 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Cheng SJ AAC 2000 GTG/ATG 415 139 Val/Met - South korea Sequencing Whole gene Z >500 Proportion method, BACTEC 460 59/59 1/0? -
Morlock GP AAC 2000 GTG/CTG 415 139 Val/Leu 1999 - Sequencing Whole gene Z 100 Proportion method 37/60 1/0 -
Morlock GP AAC 2000 GTG/GGG 416 139 Val/Gly 1999 - Sequencing Whole gene Z >800 Proportion method 37/60 1/0 - -
Sreevatsan S AAC 1997 GTG/GCG 416 139 Val/Ala 1996 Diverse geographical locations Sequencing Whole gene Z - BACTEC 460 67/118 1/0 -
Scorpio A AAC 1997 del TG 416 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Cheng SJ AAC 2000 CGC/AGC 418 140 Arg/Ser - - Sequencing Whole gene Z - Proportion method, BACTEC 460 59/59 20/0 -
Lemaitre N AAC 1999 del 68bp 419 - Frameshift 1992 France Sequencing Whole gene ZHRE 1000 - 19/35 1/0 - -
Cheng SJ AAC 2000 ins G 420 - Frameshift - USA Sequencing Whole gene ZR >900 Proportion method, BACTEC 460 59/59 1/0 - -
Cheng SJ AAC 2000 ins GG 420 - Frameshift - USA Sequencing Whole gene ZHRSO >900 Proportion method, BACTEC 460 59/59 1/0 - -
Lee KW J Korean Med Sci 2001 CAG/TAG 421 141 Gln/STOP 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Scorpio A Nature Med 1996 CAG/CCG 422 141 Gln/Pro - USA Sequencing Whole gene MDR >500ug/ml Pzase testing by Wayne's method invitro 1/0 -
Escalante P TuberLung Dis 1998 ACG/CCG 424 142 Thr/Pro 1995, 1996 Peru Sequencing Whole gene MDR - Proportion method 40146 1/0 rpoB, 516, GAC/TAC -
Hirano K TLD 1997 ACG/GCG 424 142 Thr/Ala 1997 Myanmar Sequencing Whole gene ZHRSE >800 Middlebrook 7H11 agar w/ pH of 6.0 33/168 1/0 - -
Scorpio A AAC 1997 ACG/AAG 425 142 Thr/Lys 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 -
Scorpio A AAC 1997 ACG/ATG 425 142 Thr/Met 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Cheng SJ AAC 2000 ins GG 428 - Frameshift - South korea Sequencing Whole gene Z >100 Proportion method, BACTEC 460 59/59 1/0? - -
Lee KW J Korean Med Sci 2001 GCG/ACG 436 146 Ala/Thr 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Lemaitre N AAC 1999 del G 436 - Frameshift 1987 France Sequencing Whole gene ZHRE 1000-1500 - 19/35 1/0 - -
Hirano K TLD 1997 GCG/GTG 437 146 Ala/Val 1997 India Sequencing Whole gene ZRS >800 Proportion method 33/168 1/0 - -
Peridgao J MDR 2008 ins CG 439 - Frameshift 2003 Portugal Sequencing Whole gene ZHRS - MGIT 960 48/58 1/0 - -
Sekiguchi JI JCM 2007 CGC/AGC 442 148 Arg/Ser 2006 Poland Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Brown TJ JMedMicro 2000 C/A 442 148 Arg/Ser 2000 Turkey Sequencing Whole gene ZHRP - BACTEC 460 13/18 1/0 C2431G(rpoB) -
Scorpio A AAC 1997 del G 443 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Cheng SJ AAC 2000 del 8bp 446 - Frameshift 1990-1992 Canada Sequencing Whole gene ZHRE >300 Proportion method, BACTEC 460 59/59 1/0 -
Scorpio A AAC 1997 ins 8bp 446 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Lee KW J Korean Med Sci 2001 del T 452 - Frameshift 2001 South Korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Morlock GP AAC 2000 ACC/AAC 458 153 Thr/Asn 1999 - Sequencing Whole gene Z 800 Proportion method 37/60 1/0 - -
Marttila HJ AAC 1999 AGG/GGG 460 154 Arg/Gly 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 1/0 not tested -
Lemaitre N AAC 1999 GTG/GGG 464 155 Val/Gly 1987 France Sequencing Whole gene ZHRE 1500 - 19/35 1/0 -
Escalante P TuberLung Dis 1998 GTG/GCG 464 155 Val/Ala 1995, 1996 Peru Sequencing Whole gene ZHRES - Proportion method 40146 1/0 "katG, 315, AGC/ACC; rpoB, 531, TCG/TTG; " -
Lee KW J Korean Med Sci 2001 ins T 465 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 2/0 - -
Scorpio A AAC 1997 del C 475 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 CTG/CCG 476 159 Leu/Pro 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -
Lee KW J Korean Med Sci 2001 CTG/CGG 476 159 Leu/Arg 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 ACA/CCA 478 160 Thr/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Lee KW J Korean Med Sci 2001 ins TGAC 480 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Marttila HJ AAC 1999 GCG/CCG 481 161 Ala/Pro 1994-1997 Russia Sequencing Whole gene Z - BACTEC 460 36/44 2/0 not tested
Chan RCY JAC 2007 GGT/GAT 485 162 Gly/Asp 1994-2004 Hong Kong PCR-SSCP , Sequencing Whole gene ZOREth 100mg/L BACTEC MGIT 960 89/250 1/0 "Asp94Gly (gyrA); Ser531Leu(rpoB); Met306Val(embB)"
Hou L Epi Infect 2000 ins CG 501 - Frameshift 1996-1998 China PCR-SSCP Whole gene ZSHE 900 Proportion method, BACTEC 460 35/65 1/0 - -
Cheng SJ AAC 2000 ACC/AAC 503 168 Thr/Asn - Canada Sequencing Whole gene ZRO 300 Proportion method, BACTEC 460 59/59 1/0 - -
Mestdagh M AAC 1999 GCG/ACG 511 171 Ala/Thr 1999 Bangladesh Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Sachais BS MolDiag 1998 GCG/CCG 511 171 Ala/Pro 1993-1999 USA Sequencing Whole gene Z - BACTEC at pH 6.4 39856 1/0 - -
Mestdagh M AAC 1999 GCG/GTG 512 171 Ala/Val 1999 Scotland Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Rodrigues V de F AAC 2005 GCG/GAG 512 171 Ala/Glu 1998-2003 Brazil Sequencing Whole gene Z - Proportion method 59 40 -
Mestdagh M AAC 1999 del C 512 - Frameshift 1999 Rwanda Sequencing Whole gene Z - BACTEC 460 23/62 1/0 - -
Hirano K TLD 1997 CTG/CCG 515 172 Leu/Pro 1997 Canada Sequencing Whole gene ZHRSE >800 Proportion method 33/168 1/0 -
Mestdagh M AAC 1999 CTG/GCG 514-515 172 Leu/Ala 1999 Belgium Sequencing Whole gene Z - BACTEC 460 23/62 2/0 - -
Scorpio A AAC 1997 ins 5bp 518 - Frameshift 1992-1995 - PCR-SSCP Whole gene Z >900ug/ml Pzase testing by Wayne's method 46/46 1/0 - -
Sekiguchi JI JCM 2007 ATG/GTG 523 175 Met/Val 2006 Japan Multi-plex PCR Whole gene Z - Proportion method, rapid broth method 17/138 1/0 - -
Lee KW J Korean Med Sci 2001 ins C 532 - Frameshift 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 AGC/CGC 535 179 Ser/Arg 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Lee KW J Korean Med Sci 2001 GTC/TTC 538 180 Val/Phe 2001 South korea Sequencing Whole gene Z - PZase test with Wayne's method 92/95 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 GAG/GAT 543 181 Glu/Asp 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 - -
Lemaitre N AAC 1999 TTG/TCG 545 182 Leu/Ser 1997 France Sequencing Whole gene ZHRS 500-2000ug/ml - 19/35 1/0 - -
Louw GE Int J Tuberc Lung Dis 2006 AGC/ACC 554 185 Ser/Thr 2001-2002 South Africa Sequencing Whole gene ZHRSEthK - BACTEC MGIT 960 115 68 -

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

© 2010 Andreas Sandgren  |  Supported by the Swedish Research Council  |  Contact Database Curator