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Rv2428 More about Rv2428 on TBDB.org More about Rv2428 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2428: promoter region: 31 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Rindi L Int J Tuberc Lung Dis 2005 | G/A | -74 | -74 | - | 1994-2002 | Italy | Sequencing | nt 583-819 | 36H,9MDR | 0.1ug/ml | BACTEC 460 | 45/45 | 1/0 | not mentiond | - |
| Huang WL JCM 2009 | G/A | -66 | -66 | - | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 2/0 | not mentiond | - |
| Rindi L Int J Tuberc Lung Dis 2005 | C/T | -54 | -54 | - | 1994-2002 | Italy | Sequencing | nt 583-819 | 36H,9MDR | 0.1ug/ml | BACTEC 460 | 45/45 | 1/0 | not mentiond | - |
| Gagneux S PLOS Path 2006 | ins ATGT | -54 | -54 | - | - | - | - | - | - | - | - | - | - | - | - |
| No Publication Listed | C/T | -52 | -52 | - | - | - | - | - | - | - | - | - | - | - | - |
| Doustdar F MDR 2008 | T/G | -49 | -49 | - | 2005-2006 | Iran | Sequencing | 250bp around 315 and 212 bp around 463, 238bp of inhA and 293bp of ahpC | H | N.S. | Proportion method | 48/93 | 1/0 | None | - |
| Ramaswamy SV AAC 2003 | G/A | -48 | -48 | - | - | - | - | - | - | - | - | - | - | - | - |
| Lee ASG AAC 1999 | G/A | -46 | -46 | - | 1994-1996 | Singapore | Sequencing | oxyRahpC intergenic region | H | 0.1ug/ml | BACTEC 460 | 160/192 | 1/0 | katG del/mut or inhA mutation |  |
| Secondary Publication: Hazbon MH AAC 2006 | del G | -46 | -46 | - | - | - | - | - | - | - | - | - | - | - | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | C/T | -45 | -45 | - | - | - | - | - | - | - | - | - | - | - | - |
| Sreevatsan S AAC 1997 (*) | T/A | -44 | -44 | - | 1997 | Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | oxyRahpC intergenic region | - | - | Proportion method, BACTEC 460 | 70/169 | 1/0 | katG deletion | - |
| Silva MS JCM 2003 | T/C | -40 | -40 | - | 1996-1999 | Brazil | PCR-SSCP, Sequencing | oxyRahpC intergenic region | H,HR,HRS,HRP,HS,HRE,HRES,HRESP | - | Proportion method | 69/69 | 1/0 | S315T kat G | - |
| Silva MS JCM 2003 | C/T | -39 | -39 | - | 1996-1999 | Brazil | PCR-SSCP, Sequencing | oxyRahpC intergenic region | H,HR,HRS,HRP,HS,HRE,HRES,HRESP | - | Proportion method | 69/69 | 2/0 | none | |
| Baker LV AAC 2005 | T/A | -34 | -34 | - | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | oxyRahpC intergenic region | H,HS,HE,HSE,MDR | ratio>=1 | Resistance ratio method | 202/378 | 1/0 | Arg463Leu katG | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | T/C | -34 | -34 | - | - | - | - | - | - | - | - | - | - | - | - |
| Baker LV AAC 2005 | del T | -34 | -34 | - | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | oxyR'-ahpC intergenic region | H,HS,HE,HSE,MDR | ratio>=1 | Resistance ratio method | 202/378 | 1/0 | S315T, Arg463Leu katG | - |
| Sreevatsan S AAC 1997 (*) | G/A | -32 | -32 | - | 1997 | Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | oxyRahpC intergenic region | H | - | BACTEC 460 radiometric method or Proportion method for MTB and Mafricanum isolates only | 70/169 | 1/0 | none | - |
| Huang WL JCM 2009 | C/T | -32 | -32 | - | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 1/0 | not mentiond | - |
| Lee ASG AAC 1999 | C/T | -30 | -30 | - | 1994-1996 | Singapore | Sequencing | oxyRahpC intergenic region | H | 0.1ug/ml | BACTEC 460 | 160/192 | 2/0 | katG del/mut or inhA mut | - |
| Baker LV AAC 2005 | C/T | -20 | -20 | - | 1998 | United Kingdom | Directed Oligonucleotide array, Sequencing | oxyRahpC intergenic region | H,HS,HE,HSE,MDR | ratio>=1 | resistance ratio method | 202/378 | 1/0 | none | - |
| Gagneux S PLOS Path 2006 | C/T | -15 | -15 | - | - | - | - | - | - | - | - | - | - | - | - |
| Lee ASG AAC 1999 | C/T | -12 | -12 | - | 1994-1996 | - | - | - | - | - | - | - | - | - | - |
| Gagneux S PLOS Path 2006 | C/A | -10 | -10 | - | - | - | - | - | - | - | - | - | - | - | - |
| Gagneux S PLOS Path 2006 | C/T | -10 | -10 | - | - | - | - | - | - | - | - | - | - | - | - |
| Secondary Publication: Hazbon MH AAC 2006 | C/G | -10 | -10 | - | - | - | - | - | - | - | - | - | - | - | - |
| Silva MS JCM 2003 | G/A | -9 | -9 | - | 1996-1999 | Brazil | PCR-SSCP, Sequencing | Promoter region of ahpC | H,HR,HRS,HRP,HS,HRE,HRES,HRESP | - | Proportionmethod on Ogawa medium | 69/69 | 1/0 | none | - |
| Lee ASG AAC 1999 | G/A | -6 | -6 | - | 1994-1996 | Singapore | Sequencing | Promoter region of ahpC | H | 0.1ug/ml | BACTEC 460 | 160/192 | 1/0 | katG del/mut or inhA mut | - |
| Huang WL JCM 2009 | G/A | -5 | -5 | - | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 1/0 | not mentiond | - |
| Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998 | A/G | -4 | -4 | - | - | - | - | - | - | - | - | - | - | - | - |
| Huang WL JCM 2009 | ins A | -4 | -4 | - | 2007-2008 | Taiwan | Sequencing | N.S. | 242MDR | N.S. | MGIT 960 | 242/272 | 1/0 | not mentiond | - |
| Secondary Publication: Hazbon MH AAC 2006 | ins T | -4 | -4 | - | - | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |