TBDReaMDB: INH: Rv2428

Rv2428

More about Rv2428 on TBDB.org

More about Rv2428 on TubercuList

Return to gene list

Display all mutations or select a bar from the histogram above to examine in greater detail

Display high confidence mutations only

Rv2428: all mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Rindi L Int J Tuberc Lung Dis 2005	G/A	-74	-74	-	1994-2002	Italy	Sequencing	nt 583-819	36H,9MDR	0.1ug/ml	BACTEC 460	45/45	1/0	not mentiond	-
Huang WL JCM 2009	G/A	-66	-66	-	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	2/0	not mentiond	-
Rindi L Int J Tuberc Lung Dis 2005	C/T	-54	-54	-	1994-2002	Italy	Sequencing	nt 583-819	36H,9MDR	0.1ug/ml	BACTEC 460	45/45	1/0	not mentiond	-
Gagneux S PLOS Path 2006	ins ATGT	-54	-54	-	-	-	-	-	-	-	-	-	-	-	-
No Publication Listed	C/T	-52	-52	-	-	-	-	-	-	-	-	-	-	-	-
Doustdar F MDR 2008	T/G	-49	-49	-	2005-2006	Iran	Sequencing	250bp around 315 and 212 bp around 463, 238bp of inhA and 293bp of ahpC	H	N.S.	Proportion method	48/93	1/0	None	-
Ramaswamy SV AAC 2003	G/A	-48	-48	-	-	-	-	-	-	-	-	-	-	-	-
Lee ASG AAC 1999	G/A	-46	-46	-	1994-1996	Singapore	Sequencing	oxyRahpC intergenic region	H	0.1ug/ml	BACTEC 460	160/192	1/0	katG del/mut or inhA mutation
Secondary Publication: Hazbon MH AAC 2006	del G	-46	-46	-	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	C/T	-45	-45	-	-	-	-	-	-	-	-	-	-	-	-
Sreevatsan S AAC 1997 (*)	T/A	-44	-44	-	1997	Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA	Sequencing	oxyRahpC intergenic region	-	-	Proportion method, BACTEC 460	70/169	1/0	katG deletion	-
Silva MS JCM 2003	T/C	-40	-40	-	1996-1999	Brazil	PCR-SSCP, Sequencing	oxyRahpC intergenic region	H,HR,HRS,HRP,HS,HRE,HRES,HRESP	-	Proportion method	69/69	1/0	S315T kat G	-
Silva MS JCM 2003	C/T	-39	-39	-	1996-1999	Brazil	PCR-SSCP, Sequencing	oxyRahpC intergenic region	H,HR,HRS,HRP,HS,HRE,HRES,HRESP	-	Proportion method	69/69	2/0	none
Baker LV AAC 2005	T/A	-34	-34	-	1998	United Kingdom	Directed Oligonucleotide array, Sequencing	oxyRahpC intergenic region	H,HS,HE,HSE,MDR	ratio>=1	Resistance ratio method	202/378	1/0	Arg463Leu katG	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	T/C	-34	-34	-	-	-	-	-	-	-	-	-	-	-	-
Baker LV AAC 2005	del T	-34	-34	-	1998	United Kingdom	Directed Oligonucleotide array, Sequencing	oxyR'-ahpC intergenic region	H,HS,HE,HSE,MDR	ratio>=1	Resistance ratio method	202/378	1/0	S315T, Arg463Leu katG	-
Sreevatsan S AAC 1997 (*)	G/A	-32	-32	-	1997	Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA	Sequencing	oxyRahpC intergenic region	H	-	BACTEC 460 radiometric method or Proportion method for MTB and Mafricanum isolates only	70/169	1/0	none	-
Huang WL JCM 2009	C/T	-32	-32	-	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	1/0	not mentiond	-
Lee ASG AAC 1999	C/T	-30	-30	-	1994-1996	Singapore	Sequencing	oxyRahpC intergenic region	H	0.1ug/ml	BACTEC 460	160/192	2/0	katG del/mut or inhA mut	-
Baker LV AAC 2005	C/T	-20	-20	-	1998	United Kingdom	Directed Oligonucleotide array, Sequencing	oxyRahpC intergenic region	H,HS,HE,HSE,MDR	ratio>=1	resistance ratio method	202/378	1/0	none	-
Gagneux S PLOS Path 2006	C/T	-15	-15	-	-	-	-	-	-	-	-	-	-	-	-
Lee ASG AAC 1999	C/T	-12	-12	-	1994-1996	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	C/A	-10	-10	-	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	C/T	-10	-10	-	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Hazbon MH AAC 2006	C/G	-10	-10	-	-	-	-	-	-	-	-	-	-	-	-
Silva MS JCM 2003	G/A	-9	-9	-	1996-1999	Brazil	PCR-SSCP, Sequencing	Promoter region of ahpC	H,HR,HRS,HRP,HS,HRE,HRES,HRESP	-	Proportionmethod on Ogawa medium	69/69	1/0	none	-
Lee ASG AAC 1999	G/A	-6	-6	-	1994-1996	Singapore	Sequencing	Promoter region of ahpC	H	0.1ug/ml	BACTEC 460	160/192	1/0	katG del/mut or inhA mut	-
Huang WL JCM 2009	G/A	-5	-5	-	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	1/0	not mentiond	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	A/G	-4	-4	-	-	-	-	-	-	-	-	-	-	-	-
Huang WL JCM 2009	ins A	-4	-4	-	2007-2008	Taiwan	Sequencing	N.S.	242MDR	N.S.	MGIT 960	242/272	1/0	not mentiond	-
Secondary Publication: Hazbon MH AAC 2006	ins T	-4	-4	-	-	-	-	-	-	-	-	-	-	-	-
Gagneux S PLOS Path 2006	T/C	0	0	-	-	-	-	-	-	-	-	-	-	-	-
Lee ASG AAC 1999	CCA/TCA	4	2	Pro/Ser	1994-1996	Singapore	Sequencing	Promoter region of ahpC	H	0.1ug/ml	BACTEC 460	160/192	1/0	katG del/mut or inhA mut	-
Kiepiela P Tuber Lung Dis 2000	CTG/AAG	7	3	Leu/Lys	1995	South Africa	PCR-SSCP, Sequencing	N.S	H	>8ug/ml	BACTEC 460	79/96	1/0	Pro2Pro ahpC, katG mut present but not specified	-
Lee ASG AAC 1999	ACC/ATC	14	5	Thr/Ile	1994-1996	Singapore	Sequencing	Promoter region of ahpC	H	0.1ug/ml	BACTEC 460	160/192	1/0	katG del/mut or inhA mut	-
Silva MS JCM 2003	TTC/ATC	28	10	Phe/Ile	1996-1999	Brazil	PCR-SSCP, Sequencing	Promoter region of ahpC	H,HR,HRS,HRP,HS,HRE,HRES,HRESP	-	Proportionmethod on Ogawa medium	69/69	1/0	S315T katG	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	GAC/AAC	97	33	Asp/Asn	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Hazbon MH AAC 2006	GAC/CAC	217	73	Asp/His	-	-	-	-	-	-	-	-	-	-	-
Chan RCY JAC 2007	GAG/AAG	226	76	Glu/Lys	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	2	-
Secondary Publication: Hazbon MH AAC 2006	CTC/CGC	572	191	Leu/Arg	-	-	-	-	-	-	-	-	-	-	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.