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Rv2427A More about Rv2427A on TBDB.org More about Rv2427A on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2427A: all mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Sreevatsan S AAC 1997 (*) | A/C | 331 | 110 | - | 1997 | Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | Whole gene | H | - | Proportion method, BACTEC 460 | 70/181 | only in susceptible | not mentioned | - |
| Sreevatsan S AAC 1997 (*) | G/T | 325 | 108 | - | 1997 | Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | Whole gene | H | - | Proportion method, BACTEC 460 | 70/181 | 1/0 | not mentioned | - |
| Sreevatsan S Escalante P JCM 1996 (*) | G/A | 285 | 95 | - | 1996 | Brazil, Chile, Ecuador, India, Trinidad-Tobago, Mongolia, Romania, Yugoslavia, Spain, Israel, Turkey, Guinea, Algeria, Kenya, Zaire, Somalia, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | 410 bp of oxyR | - | - | - | - | - | - | - |
| Sreevatsan S AAC 1997 (*) | ins GGCG | 67 | 22 | Frameshift | 1997 | Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | Whole gene | - | - | Proportion method, BACTEC 460 | 70/181 | N.S. | not mentioned | - |
| Sreevatsan S AAC 1997 (*) | C/T | 37 | 12 | - | 1997 | Brazil, Chile, Mexico, Venezuela, Kenya, Yemen, Philippines, Japan, Netherlands, Romania, USA | Sequencing | Whole gene | - | - | Proportion method, BACTEC 460 | 70/181 | N.S. | not mentioned | - |
| Lee ASG AAC 1999 | C/A | 28 | 9 | - | 1994-1996 | Singapore | Sequencing | promoter region of ahpC | H | 0.1ug/ml | BACTEC 460 | 160/192 | 1/0 | mostly S315T katG or inhA promoter mutation | - |
| Lee ASG AAC 1999 | G/T | 27 | 9 | - | 1994-1996 | Singapore | Sequencing | promoter region of ahpC | H | 0.1ug/ml | BACTEC 460 | 160/192 | 1/0 | mostly S315T katG or inhA promoter mutation | - |
| Lee ASG AAC 1999 | G/A | 18 | 6 | - | 1994-1996 | Singapore | Sequencing | promoter region of ahpC | H | 0.1ug/ml | BACTEC 460 | 160/192 | 39814 | mostly S315T katG or inhA promoter mutation | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |