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Rv2245 More about Rv2245 on TBDB.org More about Rv2245 on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv2245: all mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Mdluli K Science 1998 | GAT/AAT | 196 | 66 | Asp/Asn | 1998 | - | Sequencing | Whole gene | H | - | - | 28/71 | 1/0 | not mentioned | - |
| Ramaswamy SV AAC 2003 | ATG/ATA | 231 | 77 | Met/Ile | 2004 | Mexico | - | - | - | - | - | - | - | - | - |
| Lee ASG AAC 1999 | AGG/AAG | 362 | 121 | Arg/Lys | 1994-1996 | Singapore | Sequencing | Whole gene | H | 0.1ug/ml | BACTEC 460 | 160/192 | 1/0 | present but not mentioned | - |
| Mdluli K Science 1998 | GGT/AGT | 805 | 269 | Gly/Ser | 1998 | - | Sequencing | Whole gene | H | - | - | 28/71 | 1/0 | not mentioned |  |
| Mdluli K Science 1998 | GGC/AGC | 934 | 312 | Gly/Ser | - | - | Sequencing | Whole gene | H | - | - | 28/71 | 1/0 | not mentioned | - |
| Lee ASG AAC 1999 | GGC/GAC | 1160 | 387 | Gly/Asp | 1994-1996 | Singapore | Sequencing | Whole gene | H | 0.1ug/ml | BACTEC 460 | 160/192 | 1/0 | present but not mentioned | - |
| Mdluli K Science 1998 | TTC/TTA | 1239 | 413 | Phe/Leu | 1998 | - | Sequencing | Whole gene | H | 0.1ug/ml | - | 28/71 | 1/0 | not mentioned | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |