Rv0129c: fbpCRv0340Rv0341: iniBRv0342: iniARv0343: iniCRv1483: mabARv1484: inhARv1854c: ndhRv1592cRv1772Rv1908c: katG1909c: furARv2242: srm R homologRv2243: fabDRv2245: kasARv2247: accD6Rv2427A: oxyRRv2428: ahpCRv2846c: efpARv3139: fadE24Rv3566c: nhoARv3795: embB

Rv1908c

More about Rv1908c on    TBDB.org

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Display high confidence mutations only
Rv1908c: high confidence mutations (high confidence mutations are highlighted in yellow)
Primary reference Polymorphism Nucleotide position Codon position Amino acid Time period Origin Molecular detection method Gene coverage Resistance pattern MIC Susceptibility testing method R/Total isolates R/S isolates with mutation Additional mutations High confidence support
Morlock GP AAC 2003 GGC/GAC 836 279 Gly/Asp 2003 Brazil Sequencing fragment encompassing codons 249 to 342 HEth >32 I, >200 Eth Microplate alamar blue assay 17/41 1/0 D55/A ethA,L44L inhA ORF, C(-15)T inhA regulator
Haas WA AAC 1997 AGC/ATC 944 315 Ser/Ile 1997 Sierra Leone, Lesotho PCR-RFLP 892 bp central fragment HRSEth,H - - 124/212 4/0 -
Haas WA AAC 1997 AGC/AAC 944 315 Ser/Asn 1997 Free state, Gauteng, Sierra leone PCR-RFLP 890 bp fragment H,HRE,HR - - 124/212 9/0 -
Heym B MolMicro 1995 AGC/ACC 944 315 Ser/Thr 1995 Mali Ivory coast, France PCR-SSCP, Sequencing Whole gene H 1 in 4 and >5 in 1 Proportional method 34/37 5/0 -
Marttila HJ AAC 1996 AGC/ACA 944-945 315 Ser/Thr 1989-1995 Finland Sequencing Whole gene HS,HRS 1 ug/ml for I Disk elution method. 54/56 2/0 nt1501G/C katG in one
Lipin MY CMI 2007 AGC/AGA 945 315 Ser/Arg 1998-2001 Russia Sequencing nt 872-1568 HRS 1 ug/ml I, 5 ug/ml S, 20ug/ml R Absolute concentration method 217/217 2/0 335 /GTC katG in one

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.

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