TBDReaMDB: INH: Rv1908c

Rv1908c

More about Rv1908c on TBDB.org

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Rv1908c: Codons 80 to 99: 9 mutations (high confidence mutations are highlighted in yellow)
Primary reference	Polymorphism	Nucleotide position	Codon position	Amino acid	Time period	Origin	Molecular detection method	Gene coverage	Resistance pattern	MIC	Susceptibility testing method	R/Total isolates	R/S isolates with mutation	Additional mutations	High confidence support
Chan RCY JAC 2007	ATG/ATA	252	84	Met/Ile	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Gagneux S PLOS Path 2006	ACC/CCC	253	85	Thr/Pro	-	-	-	-	-	-	-	-	-	-	-
Marttila HJ AAC 1998	CAG/CGG	263	88	Gln/Arg	-	-	-	-	-	-	-	-	-	-	-
Cockerill FR JID 1995	TGG/TGA	270	90	Trp/STOP	1995	USA, Japan	Sequencing	Whole gene	-	">32; catalase 5 mm"	Proportion method	40071	1/0	none	-
Ramaswamy SV AAC 2003	TGG/CGG	271	91	Trp/Arg	-	USA, Mexico	Sequencing	-	-	2	"BACTEC radiometric method; E-test"	38/121	1/0	D3G (srmR homolog)	-
Gagneux S PLOS Path 2006	GAC/GGC	281	94	Asp/Gly	-	-	-	-	-	-	-	-	-	-	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	GAC/GCC	281	94	Asp/Ala	-	-	-	-	-	-	-	-	-	-	-
Chan RCY JAC 2007	GGC/TGC	?	96	Gly/Cys	1994-2004	Hong Kong	PCR-SSCP, Sequencing	Whole gene	N.S.	-	Absolute concentration method	250	241	1	-
Secondary Publication: Ramaswamy S Musser JM Tubercle lung Dis 1998	GGG/GAG	296	99	Gly/Glu	-	-	-	-	-	-	-	-	-	-	-

Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations.