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Rv1908c More about Rv1908c on TBDB.org More about Rv1908c on TubercuList |
Display all mutations or select a bar from the histogram above to examine in greater detail |
| Rv1908c: Codons 720 to 739: 5 mutations (high confidence mutations are highlighted in yellow) | |||||||||||||||
| Primary reference | Polymorphism | Nucleotide position | Codon position | Amino acid | Time period | Origin | Molecular detection method | Gene coverage | Resistance pattern | MIC | Susceptibility testing method | R/Total isolates | R/S isolates with mutation | Additional mutations | High confidence support |
| Ramaswamy SV J Med Micro 2004 | GCC/GAC | 2180 | 727 | Ala/Asp | 1996-1998 | Mexico | Directed Oligonucleotide array, Sequencing | codon 228-357 | HRS | >=1% growth 0.2ug/ml I, 40ug/ml R, 4ug/ml S, 2ug/ml E | Proportion method | 37/50 | 1/0 | Ser450Leu rpoB, nt491C/T rrs, Met306Ile embB | - |
| Gagneux S PLOS Path 2006 | TGG/TGT or TGG/TGC | 2184 | 728 | Trp/Cys | - | - | - | - | - | - | - | - | - | - | - |
| Gagneux S PLOS Path 2006 | del GAC | 2203-2205 | 735 | del Asp | - | - | - | - | - | - | - | - | - | - | - |
| Gagneux S PLOS Path 2006 | GAC/AAC | 2203 | 735 | Asp/Asn | - | - | - | - | - | - | - | - | - | - | - |
| Wei CJ AAC 2003 | GAC/GCC | 2204 | 735 | Asp/Ala | 2003 | - | - | - | - | - | - | - | - | - | - |
Disclaimer: These are all putative mutations found in drug resistant clinical TB isolates. No a priori decisions have been made as to whether these mutations are causally related to resistance or possible secondary mutations. |
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© 2010 Andreas Sandgren | Supported by the Swedish Research Council | Contact Database Curator |